How many days tenoten begins to act. Tenoten tablets - instructions for use. Childhood use

The drug Tenoten is a nootropic agent that has anxiolytic, stress-protective, neuroprotective, antidepressant, antiasthenic, antiamnestic and antihypoxic properties. Its chemical formula is dominated by antibodies of the S-100 protein. This protein is localized in the brain and is responsible for a person's response to any stressful situation. The substances prevailing in Tenoten are contained in a minimal dose, but at the same time they are able to suppress anxiety and emotional state, without causing drowsiness, absent-mindedness and lethargy.

Excipients are microcrystalline cellulose, lactose and magnesium stearate.

Tenoten is produced in the form of lozenges.

Among the analogues of Tenoten are Afobazol, Notta, Nervoheel, Sedavit, Fitosed, Sedafiton and Trypsidan.

Indications and contraindications for the use of Tenoten

Tenoten is recommended for patients with nervous disorders, which are characterized by the presence of constant feelings of anxiety, panic and tension. In addition, such treatment is appropriate for psychosomatic diseases, stress, as well as conditions of the central nervous system, accompanied by apathy, increased irritability, decreased activity and memory impairment.

Due to its natural origin, the list of contraindications for Tenoten is limited to hypersensitivity to the active ingredients of the drug, pregnancy and the age of up to 18 years.

As for the lactation period, the effect of Tenoten is not fully understood here, therefore it is recommended to avoid such treatment, so as not to unknowingly harm your baby.

Side effects and overdose of Tenoten

Tenoten has a mild sedative effect in the body, however, in rare clinical pictures, an exacerbation of side effects still occurs.

So, typical complaints report mild digestive disorders, expressed by flatulence and dry mouth, and allergic reactions, which are often caused by the body's sensitivity to the active components of Tenoten.

No cases of overdose were found.

Instructions for use of the drug Tenoten

Tenoten should be prescribed by a specialist, however, the instructions indicate that the method of administration and doses of Tenoten depend on the nature of the prevailing disease and the degree of its severity in the sick organism.

In general, the maximum daily dose is 12 tablets, and a single dose is one Tenoten tablet under the tongue until completely absorbed. So, with minor stresses at work, it is enough to drink one pill, and the state will return to normal; and in the case of strong emotional upheavals, it is necessary to take two tablets at a time, up to four approaches per day.

The course of treatment varies from 1 to 3 months, but in some clinical pictures it can last up to six months.

Features of the Tenoten application

Take Tenoten two hours before bedtime, and dissolve the tablets on an empty stomach.

Tenoten cannot be combined with alcohol consumption, since short-term disturbances in accommodation are possible.

The Tenoten sedative is available without a prescription and has a shelf life of 3 years.

No interaction with other drugs has been found.

Reviews about the drug Tenoten, price

This nootropic drug is in great demand in modern medicine, and many patients leave their comments about Tenoten in various medical forums.

Having systematized all the reviews studied, the conclusion is ambiguous. So, one category of patients is clearly convinced that Tenoten is a really highly effective drug, and all anxiety symptoms and nervous disorders disappear after the first pill.

The second category of patients considers this sedative to be weak, and its effect is short-term and intermittent. However, there are those patients who initially could not get enough of this treatment, but gradually began to be disappointed in it. This is simply explained: Tenoten has an addictive effect, therefore it is not recommended to use this medication for several courses in a row, it is better to alternate its reception with similar means.

The doctors' comments on Tenoten indicate that among the side effects there were complaints of severe headaches, due to which it was necessary to replace the chosen treatment regimen. The rest of the anomalies described in Tenoten's instructions are extremely rare.

Despite the fact that Tenoten is of natural origin and has a mild effect in the body, it is recommended to take it only at the insistence of a specialist, and in clearly specified doses.

Price for Tenoten lozengesNo. 40 - 155 rubles.

02:22 Tenoten: instructions, application, reviews -

Stress has a detrimental effect on human health, but since life is impossible without anxiety and experiences, stressful situations are also inevitable. In order to somehow protect themselves from unnecessary experiences and emotions, doctors often prescribe the homeopathic drug Tenoten with a sedative effect. General description of the drug Tenoten Medication Tenoten is a nootropic agent that has anxiolytic, stress-protective, neuroprotective, antidepressant, antiasthenic, antiamnestic and [...]

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The site provides background information for information only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Tenoten represents homeopathic soothing and a nootropic drug designed to relieve anxiety, nervousness and irritability, as well as improve memory, attention, perseverance and assimilation of new information. In addition, Tenoten helps to better endure high nervous and emotional stress. In complex therapy, Tenoten can be used for various organic lesions of the central nervous system, which occur with constant changes in the emotional background, irritability, memory impairment, etc.

Varieties, names and release forms

Currently, two varieties of Tenoten are produced - adult and children's, differing from each other only in the dosage of the active substance. In all other aspects, adult and child Tenoten are exactly the same. Both types of medicinal product are produced in one dosage form - oral lozenges... To designate the varieties of the drug in everyday life, the qualification "child" or "adult" is used, and almost never indicate the dosage of the active component, since the indication of who the drug is intended for is enough for a clear understanding of which version of Tenoten in question, and a doctor, and a pharmacist, and the person himself.

Tablets for children and adults Tenoten are painted white or almost white and have the shape of a cylinder flattened on both sides. There is a risk on one of the flat sides of the tablet and a chamfer on the other. Next to the notch and chamfer on the tablets of children's Tenoten, the inscriptions "MATERIA MEDICA" and "TENOTEN KID" are applied, and the inscriptions of the adult - "MATERIA MEDICA" and simply "TENOTEN".

Namely the inscriptions "TENOTEN KID" and "TENOTEN" allow you to always know for sure (even if the package is lost), which type of tablet - an adult or a child, was in the hands. Children's Tenoten tablets are available in packs of 20, 40 and 100 pieces, and for an adult - 20 and 40 pieces.

Tenoten - composition

Tenoten contains as an active ingredient water-alcohol mixture of affinity purified antibodies to brain-specific protein S-100... The similar name of the active substance is often incomprehensible, therefore, we will consider in detail what this means.

Firstly, the direct active component of adult and children's Tenoten is antibodies to the brain-specific substance S-100, and the water-alcohol mixture is only their physical state in which they are used as an active substance.

Substance S-100 in the structures of the brain regulates integrative activity (connecting information of a different nature, transmitting signals from one brain structure to another, etc.). That is, it is thanks to the S-100 protein inside the brain that signals can be quickly transmitted from one department to another, for example, from the region responsible for image perception from the eye to the cerebral cortex, which processes the received information, etc. In addition, S-100 protein protects brain cells from damaging influences and reduces the negative effects of stress. Since this protein is present only in the structures of the brain, it is called brain-specific.

However, tablets for children and adults Tenoten do not contain the S-100 protein itself, but antibodies to it, for which biotechnology is used. In the process of obtaining them, a mixture of several types of antibodies is first formed. And in order to isolate only one species from them, a special technology is used based on the property of the affinity of antibodies, which is understood as the strength of binding of antibodies to antigens (in this case, to S-100). Different types of antibodies to the same S-100 protein have different affinities, that is, they bind with different strengths. As a result of a special technology, antibodies with different affinities can be isolated, which is done to obtain the active substance of Tenoten.

So, affinity purified antibodies to the brain-specific substance S-100 are special proteins with affinity and the ability to firmly bind to S-100 proteins located in the structures of the brain.

Ready affinity purified antibodies to brain-specific protein S-100 in a certain amount are added to the water-alcohol mixture, since it is in this mixture that they can be stable and not decay. Antibodies are added to children's Tenoten at a concentration of 10 -16 ng / g, and to an adult - 10 -15 ng / g.

Then, auxiliary substances are added to the finished water-alcohol mixture with antibodies to the brain-specific protein S-100, which make it possible to form tablets (similar to how flour is added to water to make a dough). Each tablet contains 3 mg of a water-alcohol mixture of antibodies, that is, the total mass of the active substance in children's Tenoten is 3 * 10 -19 ng, and in an adult - 3 * 10 -18 ng. Thus, the mass of the active substance in children's Tenoten is 10 times less than in an adult.

The following substances are included in Tenoten for children and adults as auxiliary substances:

• Microcrystalline cellulose;
• Magnesium stearate.

What is the difference between children and adults Tenoten

The main and only difference between adult and children's Tenoten is the dosage of the active substance (antibodies to the brain-specific substance S-100). It seems to many people that the dose of the active substance in children and adults is the same, but this is not the case. And such a misconception arises due to the fact that the instruction is being read incorrectly.

So, the instructions for use indicate that each tablet of both children's and adult Tenoten contains 3 mg of the active substance, which makes a person think about their identity. However, there is an asterisk above the 3 mg number, which means that a footnote should be consulted, which indicates what the concentration of the active ingredient in these three milligrams is. For children's Tenoten, the concentration of the active substance is 10 -16 ng / g, and for an adult - 10 -15 ng / g. That is, children's Tenoten contains 3 milligrams of the mixture, the concentration of the active substance in which is 10 -16 ng / g (10 -19 ng / mg). Accordingly, an adult Tenoten contains 3 milligrams of a mixture with an active substance concentration of 10 -15 ng / g (10 -18 ng / mg). Thus, the active substance in an adult Tenoten is 10 times more than in a child.

Therapeutic effects

In experimental studies, it was found that ultra-low doses (below 10 -12 ng / g) of antibodies to the brain-specific protein S-100 normalize the impaired ability of brain cell membranes to be in an excited state and quickly transmit signals. It was on the basis of these experimental data that the drug Tenoten was created, which contains antibodies to the S-100 protein in ultra-low doses.

Due to the ability to normalize the speed and activity of signal transmission between cells and structures of the brain, Tenoten has the following therapeutic effects:

• Calming effect (the drug reduces nervous tension);
• Anti-anxiety action (the drug relieves anxiety, relieving a person of unreasonable and excessively strong anxiety for various reasons);
• Stress-protective action (the drug reduces the negative effects of stress on the brain, thereby preventing a person from losing control over themselves, soundness and clarity of reasoning, as well as emotional stability during periods of shocks);
• Antidepressant action (the drug helps to cure depression, because it has an effect similar to modern antidepressants);
• Nootropic action (the drug improves memory, attention, speed and clarity of reasoning, and also helps a person to assimilate and process large amounts of information in a short period of time);
• Antiamnestic action (the drug prevents memory impairment and amnesia);
• Antihypoxic action (the drug increases the amount of oxygen entering the structures of the brain, as a result of which the zone of damage in acute disorders of cerebral circulation is significantly reduced);
• Neuroprotective action (the drug protects the brain from the negative effects of various factors, improving the survival and vitality of its cells);
• Antiasthenic action (the drug relieves asthenia).

Thanks to its effects, Tenoten normalizes the mental state of a person, stopping depression, relieving anxiety and eliminating excitement, and at the same time improves the learning process and assimilation of new and diverse information.

Indications for use

Children's Tenoten indicated for use for children 3 - 18 years old for the treatment of the following conditions and diseases:

• Neuroses;
• Neurotic and neurosis-like disorders, proceeding with increased excitability, irritability, anxiety, impairment of memory and attention;
• Vegeto-vascular dystonia (as part of complex therapy).

Adult Tenoten indicated for use in adults over 18 years of age for the treatment of the following conditions or diseases:

• Neuroses and neurosis-like states;
• Psychosomatic illnesses (stress bleeding, abdominal pain and other manifestations of diseases that actually do not exist);
• Increased nervous tension;
• Stress causing irritability, anxiety and autonomic reactions (sweating, flushing, headaches, etc.);
• Light or moderate organic lesions of the central nervous system caused by trauma or circulatory disorders and accompanied by instability of emotions, irritability, memory impairment and autonomic reactions (sweating, hot flashes, etc.).

Tenoten - instructions for use

Tenoten for children

The tablets should be kept in the mouth (ideally under the tongue) until they are completely dissolved. If the child is not able to completely dissolve the pill, then you can dissolve it in a small amount of boiled water at room temperature and let the baby drink the ready-made solution. The tablets must be taken 15 minutes before or after meals.

In children with neuroses and neurosis-like states, Tenoten is recommended to give one tablet 1 to 3 times a day for 1 to 3 months. If necessary, the course of therapy can be extended up to six months. You can also make repeated courses of therapy, observing intervals between them lasting 1 - 2 months.

With attention deficit hyperactivity disorder in children, Tenoten is recommended to take two tablets twice a day for 1 to 3 months.

In other cases, it is recommended that the child be given one Tenoten tablet 1 - 3 times a day until a persistent improvement in the condition and relief of anxiety, depression, irritability, tantrums, as well as normalization of memory and attention.

If, after 3 - 4 weeks of continuous use of Tenoten, the child's condition has not improved, then you should stop taking the drug and consult a doctor.

Tenoten adult

Adults should not take Tenoten with food. It is enough to spread the meal and Tenoten tablets for 15 minutes (that is, take the drug 15 minutes before or after a meal). The tablets should be absorbed in the oral cavity until they are completely dissolved. It is optimal to keep them under the tongue or behind the cheek. After dissolving the tablet, it is imperative to swallow all the saliva in the oral cavity, after which, depending on subjective sensations, you can drink a few sips of clean non-carbonated water.

Adults with various conditions should take 1 - 2 tablets 2 - 4 times a day. You should start taking the drug, one tablet twice a day, and monitor your condition for a week. If after a week the state of health has not improved, then the dosage should be increased to 2 tablets 2 times a day and again to observe the condition for a week. If after this the condition has not returned to normal, then it is necessary to increase the number of doses of the drug per day, that is, drink Tenoten not 2, but 3 times a day. Thus, you should select the required dosage, starting with the minimum, and take the drug for 1 to 3 months without interruption. If the person's condition at the time of the beginning of Tenoten's administration was severe or lasted long enough, then the course of therapy can be increased to six months (6 months). In addition, if necessary, you can make repeated courses of therapy, observing intervals between them lasting at least 1 - 2 months.

If within 3 - 4 weeks from the start of taking Tenoten, the person's condition has not returned to normal and persistent improvement has not appeared, then you should stop using the drug and immediately consult a doctor.

How much Tenoten to take?

The usual course of treatment is 1 to 3 months, therefore, both adults and children need to take Tenoten at least 4 weeks. After this period, you can stop taking the drug if there are persistent improvements in the condition, and the symptoms of nervous tension, anxiety and depressed mood are completely stopped. If this does not happen, then you should continue taking Tenoten up to 3 months without interruption. In such situations, you should stop taking the drug only when, within a week, the person's condition is stably normal (acceptable).

If a person has been under the influence of stress for a long time, or he recovers for a very long time, then the duration of the course of Tenoten's use can be extended to six months. In addition, if necessary, you can repeat courses of therapy after 1 - 2 months.

In addition, it is allowed to take Tenoten one or several times in a row, one tablet 2 to 4 times a day, if necessary, to quickly calm down and relieve anxiety. In such situations, Tenoten can be seen as an effective and convenient replacement for the usual valerian.

special instructions

Since Tenoten contains substances that stimulate nervous activity, it should be taken at least two hours before going to bed. If you take the drug just before bedtime, the process of falling asleep will be very difficult.

In addition, both adult and children's Tenoten tablets contain lactose, so it is not recommended to take them to people suffering from various diseases in which the assimilation of milk sugar is difficult, such as:

• Congenital galactosemia;
• Glucose malabsorption syndrome;
• Galactose malabsorption syndrome;
• Congenital lactase deficiency.

Use during pregnancy and breastfeeding

The effect of Tenoten on the fetus and the course of pregnancy has not been studied, therefore it is not known whether the drug is safe during the period of gestation. That is why it is recommended to stop taking Tenoten during pregnancy by choosing another drug that has studied and known effects on the fetus. If the reception of Tenoten for any reason is necessary for a pregnant woman, then it should be used only if the benefits exceed all possible risks.

Since it is not known whether Tenoten passes into human milk, the drug should not be used during breastfeeding.

Overdose

Overdose was not recorded even once during the entire period of Tenoten's use.

Interaction with other medicinal products

Tenoten does not interact with other medications enough to make any difference. Therefore, the drug can be used as part of a combination therapy in combination with any other drugs.

Tenoten for children

For children from the age of three, children's Tenoten is used. If the baby is under 3 years old, then even children's Tenoten cannot be used, although in practice this is very common. So, many doctors prescribe, and parents give small children under 3 years of age half or a quarter of Tenoten tablets at one time, believing that a decrease in dosage can make the drug available and approved for babies under 3 years old.

However, the prohibition on the use of Tenoten for children under three years old is not due to the dosage of the active substance, but to the state of the child's brain, which is still being formed, and it is impossible to intervene in these processes, despite the wishes of parents or doctors. The active component of Tenoten can have a positive effect only on the brain of children over 3 years old, since by this age the necessary rather numerous neural connections and neural pathways for transmitting information from one department to another are formed in it.

Until the age of three, it is impossible to modulate the behavior of a child who does not suffer from severe diseases of the central nervous system using drugs that affect the central nervous system. Indeed, during this period, the baby forms ways of transmitting information in the brain and sets up numerous patterns of behavior, emotional reactions, responses to stress, positive and negative influences, etc. And only after these basic mechanisms, patterns of behavior and reactions are formed (on average by three years), the child can be given drugs that act on the central nervous system, including Tenoten.

Side effects

As side effects, both children and adults Tenoten can only provoke allergic reactions or phenomena of individual tolerance. However, these reactions are indicated only as likely, since at the moment there are any side effects adult and child Tenoten were not recorded even once. Therefore, the probability of allergic reactions or phenomena of individual intolerance exists theoretically, but in reality it is very low.

Contraindications for use

Adult and children's Tenoten are contraindicated for use only if an adult or a child has an individual intolerance or allergic reactions to any component of the drug. In addition, the adult Tenoten is prohibited for use by people under the age of 18, and the child should not be used until 3 years of age.

Tenoten - analogues

Currently, the analogs of any drug, including Tenoten, include synonyms and analogs themselves. Synonyms are drugs containing, like Tenoten, antibodies to the brain-specific protein S-100 as an active substance. Analogs of Tenoten are preparations containing other active substances, but with the most similar therapeutic effects.

Synonyms for Tenoten

• Brizantin tablets;
• Proproten 100 tablets and drops.

Analogs of Tenoten are the following medications:

• Adaptol tablets;
• Anvifen capsules;
• Amisil tablets;
• Afobazole tablets;
• Valerian-Heel;
• Valemidine drops;
• Valdispert tablets;
• Doppelherz Melissa drops;
• Dormikind drops;
• Dormiplant tablets;
• Lily of the valley-valerian drops;
• Mebikar tablets;
• Mebix tablets;
• Nervoheel;
• Novo-Passit solution and tablets;
• Noofen capsules;
• Notta drops and tablets;
• Passifit syrup;
• Patrimin tablets;
• Persen and Persen forte tablets;
• Selank nasal drops;
• Sympathetic pills;
• Capsule streams;
• Tranquezipam tablets and injection;
• Fezanef tablets;
• Fezipam tablets;
• Phenazepam tablets and injection;
• Fensitate tablets;
• Phenibut tablets;
• Phenorelaxan tablets and injection;
• Circulin dragee;
• Elzepam tablets and injection solution.

Reviews of the drug

About 2/3 of the reviews about Tenoten are positive, and only 1/3 are negative. The positive reviews are due to the fact that the drug helped people to eliminate anxiety and calm down at various important, but at the same time very nervous periods of time. The reviews indicate that thanks to Tenoten, strong anxiety and anxiety passed, the degree and number of negative scenarios scrolled in the head decreased, and a much calmer perception of the surrounding reality appeared without breakdowns, hysterics, fear and other similar reactions. In addition, against the background of the normalization of the psychological state, an improvement in mental activity was noted, since thoughts became clearer, clearer and more precise, which, in turn, made it possible to find the most effective ways out of the current situation.

Some reviews indicate that Tenoten helped relieve stress and nervous tension in people who quit smoking, so that they successfully achieve their goal and did not get frustrated.

Negative reviews are due to the fact that in any particular situation Tenoten turned out to be ineffective, that is, he did not have the action that the person expected. Many reviews indicate that Tenoten turned out to be ineffective when used in order to change the severity of autonomic reactions (sweating, flushing, stomach cramps, etc.) in response to screams, accusations, scandals and other situations with a high degree of nervous stress repeating regularly.

However, it is not surprising that the drug was ineffective in such situations, since Tenoten can only change the severity of the perception of stress, but is not able to make a person completely insensitive to such situations. This is why Tenoten is effective in situations where stress is unavoidable and must be dealt with (for example, illness loved one, fatigue from caring for a small child, etc.) in order to clearly and soberly assess the situation, and also have the strength to overcome the crisis. But Tenoten will be completely ineffective in cases where unpleasant and stressful situations are repeated constantly, and the person wants, in fact, not to calm down, but to make himself insensitive to them, for example, with constant or frequent nagging at work or at home, etc. Remember, Tenoten will not relieve a person of stress reactions, it can only reduce anxiety and calm down, but with a constantly repeated source of irritation, this is practically not felt.

Tenoten for children - reviews

About 2/3 of the reviews about children's Tenoten are positive, and only 1/3 are negative. Positive feedback is due to the fact that Tenoten normalized the child's condition, made him less excitable, as a result of which frequent tantrums and crying, bouts of aggression, whims stopped, the baby began to sleep better and wake up less, and also obsessive following the mother, father or others disappeared or decreased family members. In addition, many mothers in the reviews note that Tenoten improved the child's learning abilities, as a result of which he acquired new information and skills better and faster, came up with games, etc.

Separately, it is worth noting the positive feedback left by parents who gave Tenoten to their children after any severe shock they experienced, for example, trauma, evidence of something terrible (for example, a fire, a violent fight, animal abuse, etc.). These reviews indicate that Tenoten helped to normalize the child's condition, reduce the degree of his fear, stop severe nightmares, etc.

Negative reviews about Tenoten are due to the lack of the expected effect from him. For example, parents expected that under the influence of Tenoten the child would become completely calm and play calmly without whims and tantrums, but this did not happen. In such a situation, parents are disappointed and leave negative feedback, often not paying attention to the objective existing changes, which may be insignificant and not as large as we would like.

Dr. med. O. A. Shavlovskaya
First MGMU them. THEM. Sechenov, Department of Pathology of the Autonomic Nervous System, Research Center In modern neurology and psychiatry, psychotropic drugs are actively used to suppress anxiety, fear, anxiety, emotional stress or reduce the severity of these symptoms. The article provides an overview of studies on the efficacy and safety of the drug Tenoten, a new generation anxiolytic, which has a wide spectrum of action (antidepressant, nootropic, neuroprotective, etc.) in the treatment of concomitant anxiety-depressive disorders and does not cause side effects. Tenoten is actively used in neurological, psychiatric and somatic practice, in particular, for psychovegetative disorders, grade I – II discirculatory encephalopathy, cerebrovascular insufficiency in elderly patients, anxiety disorders, etc.

There is a relationship between the development of anxiety, depressive and other neurotic disorders and the brain-specific protein S100, which is expressed and secreted by microglial cells and astrocytes. Protein S100 plays an important role in the implementation of the basic functions of the neural systems of the brain, such as generation and conduction of nerve impulses, regulation of synaptic and metabolic processes, proliferation and differentiation of neurons and glial cells.

In this regard, a promising direction in the therapy of neurotic disorders is the use of drugs that regulate the activity of the S100 protein.

A fundamentally new method of regulatory action is the use of antibodies to the S100 protein. Tenoten contains ultra-low doses of affinity-purified antibodies to S100. Tenoten modifies the functional activity of the S100 protein, which ensures the neurotrophic effect of the drug, helps to restore the processes of neuronal plasticity, and prevents the development of neurotic and neurosis-like states.

The neurotrophoprotective effect of Tenoten, especially pronounced under conditions of intoxication and hypoxia of the central nervous system, the absence of a sedative and muscle relaxant effect, and its compatibility with other drugs make it promising to use the drug for the relief of neurotic symptoms accompanying various somatic diseases. The pharmacological effects of Tenoten also include stress-protective effects, regulation of the energy metabolism of neurons, and effects on the proliferation and differentiation of brain cells. In addition, Tenoten has a wide spectrum of psychotropic, neurotropic, vegetative-modulating activity. Interacting with the GABA-A-benzodiazepine receptor complex, Tenoten has a GABA-mimetic effect. The drug does not cause lethargy, daytime drowsiness, muscle relaxation, addiction and the associated withdrawal syndrome even with prolonged therapy, therefore it can be used in people leading an active lifestyle, drivers, etc. Indications for the use of Tenoten are:

1. neurotic and neurosis-like states, psychosomatic diseases;
2. stress disorders with increased nervous tension, irritability, anxiety and autonomic reactions;
3. moderately pronounced organic lesions of the central nervous system, including traumatic and dyscirculatory origin, accompanied by instability of the emotional background, irritability, memory loss, autonomic disorders.

It should be noted that for each of the areas of Tenoten application, research is being conducted in several regions of Russia by independent research teams, which undoubtedly increases the reliability of the results.

Application of the drug Tenoten in neurological practice

Tenoten in the therapy of psychovegetative disorders

Approximately one third of patients with autonomic and anxiety disorders seek help from therapists. Diagnosis of such conditions does not cause difficulties, in contrast to the choice of rational treatment. The effectiveness of the use of the drug Tenoten in the treatment of psychopathological and autonomic symptoms was studied at KB No. 83 of the FMBA of Russia (Moscow). The study involved 2 groups of patients: patients of the main group, in addition to basic therapy, were prescribed Tenoten 2 tablets 3 times a day (lasting 4 weeks), patients of the control group received only basic therapy. The main group consisted of 40 patients aged 30-60 years with a syndrome of autonomic dysfunction (psychovegetative paroxysms, tension headaches (HDN), anxiety-depressive syndrome) and organic diseases of the central nervous system (discirculatory encephalopathy (DEP) grade I-II in combination with anxiety-depressive syndrome). The control group consisted of 20 patients aged 30–60 years with diagnoses of DEP and HDN. To study the dynamics of patients' condition at the beginning and after treatment, the level of anxiety and depression was assessed using neurological and psychological research methods, as well as an integral assessment of the current functional state of the body using the Telecard device, which records autonomic parameters by ECG. Clinically, all patients complained of anxiety and decreased mood background, sleep disturbance, pain of various localization, increased fatigue, and a high level of reactive and personal anxiety. By the end of the 4th week of Tenoten therapy, these complaints regressed, a significant decrease in the level of reactive and personal anxiety was noted in comparison with the control group. According to cardiointervalography data, before the start of treatment, the patients showed excessive autonomic activation both in the ergotropic and parasympathetic circuits, which indicated an unstable autonomic status and tension of the autonomic system. After 1 week of therapy, the indicators of autonomic reactivity in the ergotropic circuit changed maximally in patients taking Tenoten, in contrast to patients in the control group. The study showed that Tenoten in a dosage of 2 tablets 3 times a day already by the end of the 1st week has a vegetative stabilizing effect, and by the end of the 4th week - a pronounced anti-anxiety effect.

Tenoten in the complex therapy of transient cerebrovascular accidents

In patients who have undergone transient cerebrovascular accident (TIA), the restoration of functional activity occurs 2 times slower if there are disturbances in the emotional sphere. An open comparative clinical and pharmacological study to assess the efficacy and safety of Tenoten in the treatment of anxiety disorders in patients with PNMC was conducted at the Central Clinical Hospital No. 1 of the Ural State Medical Academy (Yekaterinburg). We examined 60 patients who underwent PNMC, the average age was 42.1 ± 2.5 years. Patients were divided into 2 groups: patients of the main group (n \u003d 31) took Tenoten, patients of the control group (n \u003d 29) - Phenazepam.

Before and after treatment, the level of anxiety and depression was assessed using neurological and psychological research methods. In the course of the study, a significant decrease in the level of anxiety and depression was recorded. After discontinuation of Tenoten, no patient clinically and subjectively experienced withdrawal symptoms in the form of increased anxiety and deterioration of mood, while withdrawal of Phenazepam may be accompanied by a decrease in mood, increased irritability, and sleep disturbance. The study showed that the anti-anxiety effect of Tenoten in patients with PNMC is comparable to the effect of the typical benzodiazepine drug Phenazepam. However, unlike the latter, Tenoten does not cause side effects and is better tolerated by patients. That is why Tenoten can be recommended for the treatment of patients with PNMK accompanied by anxiety and mild depressive disorders.

Tenoten in the complex therapy of patients with grade I-II DEP

One of the most common reasons for a decrease in the quality of life of patients with chronic cerebrovascular disease (CVP) is psychological distress, manifested by a violation of the emotional sphere in the form of anxiety and depression. The high percentage of disability, frequent complications, and low treatment efficiency for many CVP syndromes are largely explained not only by the progression of focal neurological symptoms, but also by emotional disorders. Evaluation of the effectiveness of Tenoten in the treatment of anxiety and depression in patients with chronic CVP was carried out on the basis of the neurological department of the ICD No. 1 (Novosibirsk). Patients with grade I – II DEP were divided into 2 groups of 30 people each. In the main group (mean age 65 ± 9 years), in addition to basic therapy, Tenoten (2 tablets 3 times a day) was prescribed for 8 weeks.

Patients in the control group (mean age 60 ± 10 years) took drugs that improve cerebral circulation. To study the dynamics of the patient's condition at the beginning and after treatment, the level of anxiety and depression was assessed using clinical (changes in blood pressure (BP) indicators) and psychological research methods. After 8 weeks of therapy with Tenoten, there was a positive trend in blood pressure levels, general psychological well-being, a decrease in the severity of depressive episodes and anxiety disorders was noted. Thus, the data obtained make it possible to recommend Tenoten in the treatment of anxiety-depressive states in patients with grade I – II DEP.

Tenoten in the complex therapy of anxiety states in elderly patients with cerebrovascular insufficiency

Due to the fact that elderly patients are more sensitive to the side effects of psychotropic drugs, a comparative study of the clinical efficacy and tolerability of Tenoten and Cavinton in inpatient conditions in patients with organic pathology of the central nervous system was carried out at the Russian Gerontological Research and Clinical Center (Moscow). We examined 50 patients with a diagnosis of DEP on the background of cerebral atherosclerosis, the consequences of acute cerebrovascular accidents and post-traumatic encephalopathy. The patients were divided into 2 groups: the main group (n \u003d 30, mean age 73.5 ± 2.1 years), against the background of basic therapy, received Tenoten 1 tablet 3 times a day, the comparison group (n \u003d 20, mean age 75, 5 ± 1.8 years) - Cavinton 5 mg 3 times a day. The course of treatment is 28 days.

The dynamics of subjective complaints, neurodynamic indicators, cognitive functions, and anxiety levels were assessed. In the course of the study, a positive dynamics of subjective assessment indicators of patients, an increase in the speed of movements in the hands, a decrease in the average time for performing a test for volume and switching attention, memorization of 10 words and serial counting, significantly decreased the level of anxiety. The study of the clinical efficacy of Tenoten showed that the drug can be recommended in gerontological practice for elderly patients with DEP as an agent that improves cognitive functions and has a pronounced anti-anxiety effect.

Application of the drug Tenoten in the treatment of somatic diseases

Patients with increased anxiety are 6 times more likely to visit a cardiologist, 2.5 times more often - a rheumatologist, 2 times more often - a neurologist, urologist and ENT doctor, 1.5 times more often - a gastroenterologist and 1.5 times more often seek help from hospital. In addition, their work capacity is 2–2.5 times lower. The prevalence of neurotic and somatoform disorders with anxiety symptoms in patients with arterial hypertension (AH) can reach 51.3%.

Tenoten in the complex therapy of patients with diseases of the cardiovascular system

On the basis of the Medical-Sanitary Unit No. 25 of the Novosibirsk State Medical University, a study was carried out to assess the effectiveness and tolerability in patients with hypertension of combined treatment with antihypertensive drugs and the anti-anxiety drug Tenoten. The study involved 60 patients with hypertension (mean age 61.41 ± 6.91 years), mean duration of the disease - 10.61 ± 4.1 years. The patients were divided into two groups: the main group (n \u003d 30) included patients with grade II – III hypertension who received Tenoten against the background of basic therapy; the control group (n \u003d 30) included patients with moderate hypertension who took antihypertensive drugs. Tenoten was prescribed for 1 month according to the scheme: 6 tablets per day for the first 2 weeks, and then 1 tablet 3 times a day for another two weeks. Anxiety level and blood pressure parameters were assessed before prescribing drugs, after 2 and 4 weeks of therapy. Against the background of Tenoten therapy, the level of anxiety decreased at the 2nd week, the blood pressure values \u200b\u200bsignificantly decreased by the end of the 4th week.

Thus, it can be concluded that the inclusion of Tenoten in the complex therapy of patients with hypertension increases the effectiveness of the treatment, contributes to a more rapid onset of the hypotensive effect.

On the basis of the clinic of propedeutics of internal diseases of the St. acad. I.P. Pavlova, a comparative randomized study of the clinical efficacy and safety of the drugs Tenoten and Grandaxin (tofisopam) in the treatment of neurotic anxiety disorders in patients with diseases of the cardiovascular system was carried out. The patients were divided into 2 groups: the Tenoten group (n \u003d 31) and the Grandaxin group (n \u003d 20).

Tenoten was prescribed 1 tablet 3 times a day, Grandaxin - 50 mg 2 times a day, the course of treatment was 4 weeks. All patients were examined therapeutically, at 1, 2, 4 weeks of treatment and 4 weeks after drug withdrawal, the level of anxiety and general clinical symptoms were assessed. Against the background of Tenoten therapy, a more pronounced reduction in anxiety and somatic symptoms (blood pressure dynamics) was noted than in the Grandaxin group, a positive assessment of the overall clinical impression was given. The spectrum of the effect of Tenoten in comparison with Grandaxin on the symptoms of anxiety in patients with heart disease was more uniform, the stability of the clinical effect was more pronounced.

An assessment of the efficacy and tolerability of combination therapy with antiarrhythmic drugs and Tenoten in patients with ischemic heart disease (CHD) with extrasystole and paroxysmal supraventricular tachyarrhythmias was carried out. On the basis of GKB No. 20 named after I.S. Berzon (Krasnoyarsk) examined 60 patients with coronary artery disease, angina pectoris I – III functional class (FC), cardiac arrhythmias at the age of 42 to 79 years. The patients were divided into 2 groups: in the main group (n \u003d 30, mean age 64.4 ± 8.6 years), patients took Tenoten against the background of basic therapy, in the control group (n \u003d 30, mean age 63.1 ± 8.5 years) - only antiarrhythmic therapy. Tenoten was prescribed in a dose of 2 tablets 3 times a day, after a week the dose of the drug was reduced to 3 tablets a day. The analysis of the condition of the patients was carried out after 4 and 8 weeks using the physical method of examination, measurement of blood pressure, ECG, Holter monitoring and assessment of the level of anxiety. According to the data obtained, in patients with ischemic heart disease, angina pectoris I – III FC and cardiac arrhythmias, Tenoten had a pronounced anti-anxiety effect. A positive antiarrhythmic effect (the disappearance of paroxysmal atrial tachyarrhythmias and a decrease in the daily number of extrasystoles by at least 75%) was observed in 80% of patients in the main group and in 53.3% of the control group. A positive dynamics of angina pectoris was obtained, a decrease in the number and duration of episodes of myocardial ischemia (not less than 50% of the initial data) in the clinical picture of coronary artery disease was noted in 60% of cases in the main group and in 33.3% in the control group.

Thus, the appointment of Tenoten in combination therapy of patients with diseases of the cardiovascular system not only has a pronounced anti-anxiety effect, but also improves the course of ischemic heart disease, reducing the manifestations of angina pectoris, and also contributes to the normalization of the heart rhythm.

Similar results were obtained in a comparative study of the efficacy and tolerability of combination therapy with antihypertensive drugs and Tenoten and therapy with antihypertensive drugs in combination with the benzodiazepine drug Clonazepam in patients with hypertension. The study included 60 patients of cardiological hospitals of the First Moscow State Medical University. THEM. Sechenov and the Institute of Clinical Cardiology. A.L. Myasnikov with various diseases of the cardiovascular system.

The therapeutic diagnosis was determined taking into account the nature of cardiac arrhythmias:

1. Ischemic heart disease, angina pectoris II – III FC, AH II – III st .;
2. postmyocarditis cardiosclerosis;
3. dyshormonal myocardial dystrophy;
4. rheumatism, inactive phase, combined heart defects with various cardiac arrhythmias (sinus tachycardia, ventricular and supraventricular extrasystoles, paroxysmal atrial fibrillation, paroxysmal atrial fibrillation, paroxysmal atrial fibrillation, permanent atrial fibrillation).

All patients had anxiety spectrum disorders. The patients were divided into 3 groups:

1. 30 people (average age 54.1 ± 5.2 years) received Tenoten, 2 tablets 3 times a day;
2. 20 people (average age 59.2 ± 5.1 years) took Clonazepam (0.5-1 mg per day);
3. 10 people (mean age 57.9 ± 4.8 years) received only somatotropic therapy.

The duration of treatment with Tenoten and Clonazepam was 28 days. The state was assessed at the beginning, on the 14th and 28th days of therapy, taking into account the dynamics of the level of anxiety, depression and functional disabilities. After 4 weeks of therapy, the parameters significantly changed in the Tenoten and Clonazepam groups. When examining the somatic state of patients (in particular, the results of daily Holter monitoring), all patients noted a subjective improvement in well-being, a decrease in the intensity of hypochondriac reactions. In the course of the study, in 5 patients taking Clonazepam, at the beginning of treatment, there was a slight slowdown in mental and motor reactions, a feeling of fatigue, lethargy, and drowsiness during the day. In patients taking Tenoten, these unwanted side effects were not detected. After discontinuation of the drug at the end of the study for a week, no patient clinically and subjectively had a withdrawal syndrome in the form of increased anxiety and deterioration of the somatic state. Thus, the appointment of Tenoten is possible in the treatment of anxiety neurotic disorders in patients with diseases of the cardiovascular system, in particular, in rhythm disturbances of various etiologies. It should be noted that the psychopharmacological value of Tenoten increases significantly due to the absence of side effects, the likelihood of the formation of dependence on the drug, which is extremely important for patients with a cardiac profile.

Tenoten in the complex therapy of patients with diseases of the gastrointestinal tract

Currently, peptic ulcer disease is considered to be a multifactorial psychosomatic disease, in the pathogenesis of which emotional and psychosocial factors play a significant role. A study was conducted to assess the dynamics of the level of anxiety against the background of Tenoten therapy in patients with Helicobacter-pylori-associated duodenal ulcer. We examined 102 patients of the gastroenterology department of the clinic of the Research Institute of Medical Problems of the North of the Siberian Branch of the Russian Academy of Medical Sciences (Krasnoyarsk). The patients were divided into 2 groups: patients of the main group (n \u003d 49, age 42.3 ± 2.81 years) took Tenoten 2 tablets 3 times a day for 3 weeks, in the control group (n \u003d 53, age 41, 8 ± 2.36 years), patients received basic therapy. The dynamics of the state was assessed according to the results of the study of the level of anxiety, determination of the size of the ulcer defect during esophagogastroduodenoscopy, and a decrease in the incidence of pain in the epigastric region on the 10th and 20th days from the start of therapy. On the background of Tenoten therapy, a direct correlation was found between a decrease in the level of anxiety and the frequency of pain in the epigastric region. In the group of patients taking Tenoten, already on the 10th day from the start of therapy, more pronounced changes in indicators were noted, which significantly differed by the 20th day. Thus, the appointment of Tenoten as a complex therapy drug in patients with duodenal ulcer contributes to positive clinical dynamics in the healing of ulcerative defects.

The effectiveness of Tenoten as a means of secondary prevention of recurrence of duodenal ulcer (DU) was studied at the Department of Faculty Therapy of the Surgut state university... The study involved 25 patients with chronic gastroduodenitis (CGD) and DU in the stage of unstable remission with annual seasonal exacerbations at the age of 20-59 years, the average duration of the disease is 11.3 ± 8.5 years, the average duration of residence in the North is 24.1 ± 11.1 years. Tenoten was prescribed 1 tablet 2 times a day for a month (July - August) with the aim of secondary prevention of autumn relapses. The effectiveness of Tenoten therapy was assessed on the basis of the dynamics of the level of anxiety; the assessment of the state of autonomic regulation was carried out using the analysis of heart rate variability according to the cardiointervalogram data. Analysis of the dynamics of clinical symptoms showed that as a result of the course of treatment, the frequency of complaints of intestinal dyspepsia, heartburn, pain and discomfort in the epigastric region significantly decreased.

Against the background of the therapy with Tenoten, a significant decrease in the severity of anxiety, a significant increase in specific gravity low-frequency heart rate waves reflecting an increase in sympathetic activity.

Spectral analysis of the active orthostatic test in the group of treated patients showed an adequate increase in sympathetic tone by 1.06 times and a decrease in the parasympathetic effect by 1.76 times. As a result of the course of treatment with Tenoten, the studied parameters stabilized. Annual prophylactic use of Tenoten as an additional anti-relapse agent helps to increase the duration and quality of remission of chronic gastroduodenitis and duodenal ulcer. Dispensary observation of patients with DU and CGD during the first year after the preventive treatment with Tenoten showed that the number of clinical exacerbations (relapses) among patients in this group decreased 2.4 times, and hospitalizations - 5 times. The appointment of Tenoten in the complex therapy of CHD and DU helps to reduce the level of anxiety, stabilize autonomic homeostasis, reduce the severity of clinical symptoms and consolidate remission.

A clinical study of the effect of Tenoten on the reduction of anxiety symptoms in patients with hypomotor dyskinesias of the biliary tract was carried out. 41 patients were examined at the Department of Therapy and Clinical Pharmacology of the St. Petersburg Medical Academy of Postgraduate Education. Two groups were compared: patients in the main group (n \u003d 21, mean age 41 years) took Tenoten, patients in the control group (n \u003d 20, mean age 35 years) received basic therapy. Tenoten was prescribed 2 tablets 3 times a day, the duration of administration was 1 month.

In order to study the dynamics of the patient's condition at the beginning of therapy and after 1 month of taking Tenoten, the level of anxiety and asthenia was assessed, a subjective assessment of the effectiveness of therapy using a visual analogue scale. In addition to a significant decrease in the level of anxiety and depression, Tenoten's effect on motility was noted, which was reflected in a decrease in dyskinetic phenomena with a simultaneous increase in the contractility of the gallbladder and a decrease in the severity of pain syndrome, which makes it possible to recommend it for functional motor disorders of the cholangiopancreatoduodenal zone.

Similar data when assessing the effectiveness of Tenoten in the treatment of asthenodepressive disorders in 85 patients with cholelithiasis and irritable bowel syndrome were obtained during a study on the basis of the gastroenterology department of Kazan State Medical University. The authors came to the conclusion that the inclusion of Tenoten in the complex therapy for diseases of the digestive tract will allow much more effective treatment, in a shorter time to restore the ability to work and improve the quality of life of patients.

Application of the drug Tenoten in the treatment of neurotic disorders

At the Research Institute of Mental Health, Siberian Branch of the Russian Academy of Medical Sciences (Tomsk), a study was conducted of the clinical efficacy of Tenoten in an outpatient setting in patients with neurotic disorders and people with preneurotic conditions. 47 patients were examined, of which the main group consisted of 22 patients (mean age 42.7 ± 3.7 years) with neurotic disorders being treated at the Interdepartmental Center of Mental Health Research Institute of the Siberian Branch of the Russian Academy of Medical Sciences, another group consisted of 25 patients (mean age 40.1 ± 5.2 years) with preneurotic conditions. In the group with neurotic disorders Tenoten was prescribed 1 tablet 3 times a day, in the group with preneurotic conditions - 1 tablet 1-2 times a day, the duration of treatment was 2 weeks. The classification of pre-morbid disorders and the method of early detection of pre-morbid mental health disorders using a screening questionnaire were used.

Changes in the level of anxiety and quality of life were assessed. All patients complained of a feeling of anxiety and anxiety of a transient nature, a feeling of tension, the inability to relax and determine the importance of work, decreased ability to work, attention, mood; somatic and autonomic manifestations aggravated the condition and disrupted the usual rhythm of activity. By the end of the first week, against the background of Tenoten therapy, a positive dynamics of the state was noted: a decrease in anxiety and asthenic manifestations, a decrease in mnestic difficulties, an increase in the speed of switching attention. During the second week, vegetative manifestations stabilized, general well-being improved, interpersonal relationships were restored, productivity, mood increased, a desire for vigorous activity appeared, an increase in the quality of life was noted, a continuing decrease in anxiety levels. Thus, we can say that the drug Tenoten, which has thymoleptic and psychostimulating properties, is highly effective in the treatment of anxiety and asthenia in patients with neurotic disorders and preneurotic conditions.

Conclusion

Studies have shown the high efficiency of the drug Tenoten (2 tablets 3 times a day, 4 weeks course) in the treatment of anxiety-depressive disorders and asthenic manifestations. By the end of the 1st week, a vegetative stabilizing effect of the drug was noted, after 2 weeks - an initial decrease in the level of anxiety, which reaches its maximum manifestation by the end of the 4th week after Tenoten's appointment. In some cases (for example, DEP I-II degree), the course of treatment with Tenoten (2 tablets 3 times a day) can be extended to 8 weeks. In the case of prescribing the drug to elderly patients, the Tenoten dose is reduced to 1 tablet 3 times a day, the duration of administration is 4 weeks. Thus, based on the analysis of studies of the effectiveness of the drug Tenoten, conducted in clinics of various profiles, it is possible to draw final conclusions.

1. In patients with a neurological profile (with functional and organic diseases of the central nervous system) with psychovegetative and dyscirculatory disorders, Tenoten has a vegetative stabilizing, pronounced anti-anxiety (comparable to the benzodiazepine anxiolytic - Phenazepam) and nootropic (improving cognitive functions) effect.
2. In the complex therapy of patients with diseases of the cardiovascular system, Tenoten has a pronounced anti-anxiety effect (not inferior to benzodiazepine anxiolytics - Grandaxin and Clonazepam) and increases the effectiveness of the treatment, contributing to a more rapid decrease in blood pressure, normalization of the heart rate and a decrease in the frequency of angina attacks.
3. In the complex therapy of diseases of the digestive tract, Tenoten, in addition to a significant reduction in anxiety-depressive symptoms, helps to stabilize autonomic homeostasis, which leads to a decrease in the severity of clinical symptoms (a decrease in dyskinetic phenomena, the intensity of pain, healing of ulcerative defects, etc.) and consolidation of remission. In general, this significantly increases the effectiveness of treatment, shortens the recovery time and improves the quality of life of patients.
4. The pharmacotherapeutic value of Tenoten increases significantly due to the absence of side effects and the likelihood of the formation of dependence on the drug, which is extremely important for patients of both neurological and somatic profile.
5. In the treatment of preneurotic and neurotic disorders, Tenoten simultaneously has an anti-anxiety and asthenic effect, helps to stabilize vegetative manifestations, reduce mnestic difficulties (increases the speed of switching attention), which generally improves the general well-being and improves the quality of life of patients.

Literature

1. Amosov M.L., Saleev R.A., Zarubina E.V., Makarova T.V. The use of Tenoten in the treatment of emotional disorders in patients with transient cerebrovascular accidents // Russian Psychiatric Journal. 2008. No. 3. P. 86–89.
2. Vanchakova N.P., Popov A.P. Anxiety disorders in patients with essential hypertension and ischemic heart disease and the experience of their correction with Tenoten // Polyclinic. 2007. No. 2. P. 74–78.
3. Doronin B.M., Gribacheva I.A., Mulyarov D.F., Doronin V.B. The psychological component of the quality of life in patients with grade I – II discirculatory encephalopathy treated with Tenoten // Scientific and practical medical journal Doctor.Ru. Neurology. Psychiatry. 2008. No. 4. P. 1–4.
4. Karpin V.A., Burmasova A.V., Voronova E.I. Effect of Tenoten on neurovegetative status and consolidation of remission in patients with chronic gastroduodenitis and duodenal ulcer // Polyclinic. 2010. No. 1. P. 78–83.
5. Matyushin G.V., Yurin V.V., Golovenkin S.E., Savchenko E.A., Kuskaev A.P. Experience of using anxiolytic agent in the therapy of patients with extrasystole and paroxysmal supraventricular tachyarrhythmias // Attending physician. 2009. No. 2. P. 76–78.
6. Mukhametshina E.I., Yakhin K.K. Application of antibodies to the brain-specific protein S-100 in the treatment of neurotic disorders in patients with diseases of the digestive system // Clinician. 2008. No. 1. P. 54–57.
7. Nikolskaya I.N., Guseva I.A., Bliznevskaya E.V., Tretyakova T.V. The role of anxiety disorders in hypertension and the possibility of their correction // Attending physician. 2007. No. 3. S. 89–90.
8. Romasenko L.V., Nedostup A.V., Artyukhova M.G., Parkhomenko I.M. The use of the drug Tenoten in the treatment of neurotic disorders in patients with diseases of the cardiovascular system // Russian Psychiatric Journal. 2007. No. 2. P. 81–84.
9. Semke V.Ya., Kupriyanova I.E., Semke V.A., Dashieva B.A., Pan I.R. Therapeutic efficacy of Tenoten in outpatient psychiatric practice // Quality of life. The medicine. 2006. No. 1 (12). S. 2–6.
10. Serov a L.D. Tenoten in the complex therapy of cerebrovascular insufficiency in elderly patients // Neurology. Neuropsychiatry. Psychosomatics. 2009. No. 1. P. 41–44.
11. Simanenkov V.I., Poroshina E.G., Tikhonov S.V., Solovieva O.I. The influence of Tenoten on the course of hypomotor dyskinesias of the biliary tract // Polyclinic. 2007. No. 5. P. 92–95.
12. Tenoten: instructions for use // URL: rlsnet.ru/tn_index_id_33140.htm.
13. Tsukanov V.V., Kupershtein E.Yu., Sharypova V.N. The efficacy of the anti-anxiety drug Tenoten as part of complex therapy in patients with Helicobacter-pylori-associated duodenal ulcer // Polyclinic. 2008. No. 2. P. 52–53.
14. Shvarkov S.B., Shirshova E.V., Kuzmina V.Yu. Ultra-low doses of antibodies to the S-100 protein in the treatment of autonomic disorders and anxiety in patients with organic and functional diseases of the central nervous system // Attending physician. 2008. No. 8. S. 83–85.

Tenoten is a sedative and anti-anxiety homeopathic preparation based on affinity purified antibodies to the brain-specific protein S-100. Manufacturer - NPF Materia Medica Holding (Russia). The modern rhythm of life presupposes an abundance of stressful situations that lie in wait for a person at work and in everyday life. Constant psycho-emotional stress can negatively affect health. The drug Tenoten will help to rid the body of excessive stress. It harmonizes nervous activity, has an anxiolytic (anti-anxiety) effect, supported by nootropic and vegetotropic effects. It is important that Tenoten does not cause drowsiness or a decrease in muscle tone. The drug helps the body to cope with psycho-emotional overload, exhibits stress-protective, antiasthenic, antiamnesic, neuroprotective, antihypoxic and antidepressant effects. In conditions of oxygen starvation, intoxication, acute circulatory disorders of the brain, it localizes the focus of damage and normalizes cognitive functions. Suppresses oxidative (free radical) lipid degradation. It controls the functional activity of a marker of CNS damage - a specific protein of astrocytic glia S-100, which synchronizes synaptic and metabolic processes in the brain. An important property of the drug is its stress-protective effect. Tenoten increases the body's resistance to psycho-emotional stress, acts as an anxiolytic, eliminating increased anxiety and anxiety, restores the plasticity of the central nervous system. Thanks to the drug, the patient becomes less sensitive to negative exogenous stimuli and tunes in an optimistic mood. Tenoten is effective for mood swings, increased irritability, weakening of cognitive functions (memory impairment, attention disorder), autonomic disorders associated with traumatic effects on the brain or damage to cerebral vessels.

When using Tenoten as part of a course of drug therapy, patients showed a two-fold decrease in the level of anxiety. Vegetotropic effect of Tenoten lies in its ability to modulate blood pressure, heart rate and other autonomic reactions (rapid breathing, dizziness, chills). The use of the drug in complex therapy allows you to normalize the tone of the autonomic nervous system by the end of the first week. Tenoten in combination with psychotherapy has a pronounced nootropic and anti-asthenic effect: it increases vitality and tolerance of mental and physical stress, strengthens memory, improves attention.

Tenoten is available in tablet form. Single dose - 1 tablet. Frequency rate of application - 1-3 times a day. Method of application - absorption in the mouth. Dissolution of the tablet in a small amount of water is allowed. Food intake and drug intake should be diluted in time. The duration of drug therapy is 1-3 months with the possibility of extending it up to six months. Repeated therapeutic courses are allowed with an interval of 1-2 months. The absence of a stable improvement in the patient's condition after 3-4 weeks of regular pharmacotherapy is the basis for contacting a doctor to adjust the treatment. Undesirable side effects, subject to the recommended doses, are not characteristic of the drug. Theoretically, the possibility of an individual intolerance to the active component of Tenoten is allowed.

Release form

Lozenges from white to almost white, flat-cylindrical, with a score and a chamfer; the flat side with a line has the inscription "MATERIA MEDICA", the other flat side has the inscription "TENOTEN".

Excipients: lactose monohydrate - 267 mg, microcrystalline cellulose - 30 mg, magnesium stearate - 3 mg.

* applied to lactose in the form of a water-alcohol mixture with a content of not more than 10 -15 ng / g of the active form of the active substance.

20 pcs. - contour cell packaging (1) - cardboard packs.
20 pcs. - contour cell packages (2) - cardboard packs.

LS-000542 dated 11/18/2009

Tradename:

Dosage form:

lozenges.

Composition

Active ingredients:
Affinity purified antibodies to brain-specific protein S-100 - 0.003 g *
Excipients: lactose monohydrate (lactose) 0.267 g, microcrystalline cellulose 0.03 g, magnesium stearate 0.003 g.
* applied to lactose in the form of a water-alcohol mixture with a content of not more than 10-15 ng / g of the active form of the active substance.

Description

Tablets are flat-cylindrical, with a scored and beveled from white to almost white.
The flat side with scribble has the inscription MATERIA MEDICA, the other flat side has the inscription TENOTEN.

Pharmacotherapeutic group:

Anxiolytics, nootropics.

ATX codes N05BX, N06BX.

pharmachologic effect

The drug has a sedative, anti-anxiety (anxiolytic) effect, without causing undesirable hypnogenic and muscle relaxant effects. Improves the tolerance of psycho-emotional stress. It has stress-protective, nootropic, antiamnestic, antihypoxic, neuroprotective, antiasthenic, antidepressant effects.
In conditions of intoxication, hypoxia, in conditions after an acute disturbance of cerebral circulation, it has a neuroprotective effect, limits the zone of damage, normalizes learning and memory processes in the central nervous system (CNS).
Inhibits the processes of lipid peroxidation.
Modifies the functional activity of the S-100 protein, which links synaptic (informational) and metabolic processes in the brain. Providing GABA-mimetic and neurotrophic effects, it increases the activity of stress-limiting systems, helps to restore the processes of neuronal plasticity.

Indications for use.

Neurotic and neurosis-like states, psychosomatic diseases; stress disorders with increased nervous tension, irritability, anxiety and autonomic reactions.
Moderately expressed organic lesions of the central nervous system, including traumatic and dyscirculatory origin, accompanied by instability of the emotional background, irritability, memory loss, autonomic disorders.

Contraindications

Increased individual sensitivity to the components of the drug, children under 18 years of age; children and persons under the age of 18 are shown the use of the drug Tenoten for children.

Pregnancy and lactation

The safety of Tenoten's use in pregnant women and during lactation has not been studied. If necessary, taking the drug should take into account the risk / benefit ratio.

Method of administration and dosage

Inside. At one time - 1 or 2 tablets (keep in the mouth until completely dissolved - not during meals). Take 2 times a day; if necessary - up to 4 doses per day. The course of treatment is 1-3 months; if necessary, the course of treatment can be extended up to 6 months or repeated after 1-2 months.
If there is no persistent improvement in the condition within 3-4 weeks after the start of treatment, you should consult a doctor.

Side effect

When used according to the indicated indications and at the indicated dosages side effects not found.
Possible reactions of increased individual sensitivity to the components of the drug.

Overdose

Overdose cases have not been identified so far.

Interaction with other medicinal products

No cases of incompatibility with other drugs have been registered to date.

special instructions

The drug contains lactose, and therefore it is not recommended to prescribe it to patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or with congenital lactase deficiency.
Due to the presence of activating properties in the action of Tenoten, the last dose should be carried out no later than 2 hours before bedtime.

Release form

Lozenges. 20 tablets in a blister strip made of polyvinyl chloride film and aluminum foil. 1 or 2 blister packs, together with instructions for medical use, are placed in a cardboard box.

Storage conditions

At a temperature not higher than 25 ° C.
Keep out of the reach of children.
During the period of use of the drug, store the blister strip in a cardboard box provided by the manufacturer.

Shelf life

3 years
Do not use after the expiration date.

Pharmacy dispensing conditions

Without recipe.

Name, address of the manufacturer of the medicinal product / organization accepting the claims

LLC NPF MATERIA MEDICA HOLDING;
Russia, 127473, Moscow, 3rd Samotechny per., 9.

Medicinal product manufacturing site address.
454139, Chelyabinsk, st. Buguruslanskaya, 54.