Glucosamine chondroitin complex n90 caps. Chondroitin, glucosamine Interaction with other drugs
Glucosamine is a chondroprotective agent that stimulates metabolic processes in bone and cartilage tissues. It is one of the most effective remedies for the treatment and restoration of joints and synovial fluid in them.
The pharmaceutical product Glucosamine refers to medicines that fight diseases such as arthritis, osteochondrosis and arthrosis. Also, thanks to the use of Glucosamine, cartilage is formed and a layer is formed between the ends of the bones, which rub against each other.
The component of the drug (active ingredient) is glucosamine sulfate. It is a salt of the natural amino-monosaccharide glucosamine, an analogue of endogenous glucosamine. This compound is involved in the normal synthesis of the connective tissues of the cartilage.
Glucosamine promotes the production of hyaluronic acid and other substances that make up the synovial fluid, articular membranes and cartilage. The mechanism of action of glucosamine sulfate is to stimulate the production of glycosaminoglycans and, accordingly, articular proteoglycans.
Actually, the very substance glucosamine is present in small quantities in the human body in its natural form. It is produced as a result of physiological processes in the body, and helps to increase the extensibility of cartilage tissue. In addition, glucosamine exhibits the effect of a natural immunomodulator.
The course administration of the drug Glucosamine promotes the fixation of sulfur during the synthesis of chondroitinsulfuric acid, facilitates the normal deposition of calcium in bone tissue, inhibits the development of degenerative processes in the joints, restores their function and reduces pain.
The medication is available in the form of tablets, capsules, a solution intended for intramuscular administration, and a powder for preparing a solution for oral administration.
- 1 coated tablet, Glucosamine contains: glucosamine sulfate - 750 mg.
- 1 capsule (powder in a gelatinous shell) Glucosamine contains: glucosamine sulfate - 750 mg.
- 1 ampoule of 2 ml contains: glucosamine sulfate - 400 mg.
- 1 sachet of powder for preparation of solution for oral administration Glucosamine contains: glucosamine sulfate - 1500 mg.
Indications for use Glucosamine
According to the instructions, the medication is prescribed for the symptomatic treatment of osteoarthritis, arthrosis, osteochondrosis - pain and limited movement of the joints.
Indications for the use of Glucosamine are degenerative-dystrophic diseases of the spine and joints, manifested by the following symptoms:
- patient complaints of loss of sensitivity and crunching in the joints;
- feeling of stiffness in the joints;
- painful sensations in the spine and joints;
- the development of inflammatory processes in the joints;
- inflammation of the tendons;
- injuries and damage to joints;
- joint pain when walking, squatting, bending.
Also, Glucosamine for joints is prescribed for athletes and people leading an active lifestyle or engaged in hard physical labor, to protect joints during intense physical activity and sports.
Instructions for use Glucosamine, dosages
Adults are prescribed to take Glucosamine tablets inside 1.5 g per day once. The course of treatment is usually 6 weeks, and, if necessary, longer.
Intramuscular injections (injections)
For an injection, Glucosamine must be prepared - one dosage of the drug is mixed with a solvent and 3 ml of the resulting solution is injected at 400 mg 3 times a week for 4 to 6 weeks, then a break in therapy is taken.
Can be combined with oral administration of tablets or capsules at the same time.
Taking pills / capsules
1-2 tablets or 1-2 capsules of Glucosamine per day, always with meals (750-1500 mg).
Powder intake
The contents of 1 sachet or sachet (powder for suspension preparation), previously dissolved in a glass of water, are taken once a day with meals (1500 mg). Adult patients with arthrosis and osteoarthritis are usually prescribed 1 sachet of the drug per day.
The duration of therapy and the dose of Glucosamine is determined by the doctor.
Features of the use of Glucosamine
In case of drowsiness, increased fatigue, dizziness, loss of coordination or visual impairment, as side effects for taking Glucosamine, driving and working with potentially dangerous mechanisms is prohibited.
It is undesirable to consume alcoholic beverages simultaneously with Glucosamine, since ethanol reduces the effectiveness of the active substance of the drug.
It is not recommended to take this medicine during pregnancy, since the effect of the active substance on the development and condition of the fetus has not yet been fully understood. For the same reason, it is contraindicated to be treated with Glucosamine during lactation.
A noticeable improvement in the condition of the joints occurs 2 weeks after the start of oral use of the drug, and after only 4 days with the injection route of administration (Glucosamine injections).
Side effects Glucosamine, contraindications
During the period of therapy with the drug Glucosamine, it is possible to develop pain in the epigastric region and the occurrence of side effects such as: stool disorders, flatulence, as well as headache, dizziness, drowsiness, weakness, short-term loss of working capacity and skin hypersensitivity reactions.
Glucosamine sulfate solution for intramuscular administration additionally (due to the content of lidocaine in the composition): vomiting, drowsiness, diplopia, headache, dizziness, numbness of the tongue and oral mucosa, tremor, euphoria, disorientation, impaired cardiac conduction.
Overdose
Overdose is not described in official sources and is unlikely.
In case of accidental intake of the drug in doses significantly exceeding the recommended ones, gastric lavage should be performed and enterosorbent agents should be prescribed.
Contraindications
Glucosamine is not prescribed to patients with known hypersensitivity to the components that make up the powder or tablets (including lidocaine - for a solution for intramuscular administration).
Glucosamine should not be used to treat patients with phenylketonuria and severe renal impairment.
In pediatric practice, the drug Glucosamine is used only for the treatment of children over 15 years of age.
Analogs Glucosamine, list of drugs
- Aminoarthrin;
- Glucosamine Sulfate;
- Glucosamine sulfate 750;
- Don;
- Pharmaskin THC;
- Elbon;
- Unium.
Important - instructions for the use of Glucosamine, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Glucosamine with an analogue, it is important to consult a specialist, you may need to change the course of therapy, dosages, etc. Do not self-medicate!
The systematic intake of Glucosamine allows you to restore the elasticity of the joints, expand the mode of physical activity and improve the quality of life in the presence of chronic pathologies of the musculoskeletal system. The same effect is fixed for a sufficiently long time, after undergoing a course of therapy with this drug.
Glucosamine is on the over-the-counter pharmacy list. The doctors' comments on Glucosamine are mostly positive and based on the fact that its use allows you to quickly relieve pain symptoms in destructive diseases of cartilaginous tissues.
Description and instructions for Glucosamine maximum tab. No. 30:
Glucosamine Maxium
MANUFACTURERS
Natur Product Europe B.V. (Netherlands)
GROUP
Regeneration stimulating agents
INTERNATIONAL NON-PATENTED NAME
not
DESCRIPTION
pharmachologic effect
GLUCOSAMINE MAXIMUM is a combination of glucosamine and chondroitin, which have been used for many years by doctors around the world for the prevention and complex treatment of diseases of the musculoskeletal system, including osteoarthritis.
Glucosamine and chondroitin are natural components of articular cartilage, necessary for the normal synthesis of the connective tissue of the cartilage and helping to prevent the destruction of cartilage.
The interaction of these components and the high content of the active substance provide a pronounced and lasting beneficial effect on the joints and spine.
Helps to improve the condition with:
... pain in joints and spine
... stiffness in movements and crunching in joints
... inflammation of the joints
Glucosamine Maximum can be used at the first signs of impaired activity of the musculoskeletal system, as well as those who are at risk for the prevention of diseases.
Glucosamine Maximum is a reliable basis for constructive prevention of diseases of the musculoskeletal system and an essential component of the daily diet of people suffering from diseases of the joints and spine.
Method of administration and dosage
Adults take 1 tablet daily with meals, which provides an adequate level of glucosamine sulfate consumption by 100% (750 mg), chondroitin sulfate by 60% (250 mg).
Duration of admission is 2 months.
It is recommended to consult a doctor before use.
Storage conditions
Store at a temperature not exceeding + 25 ° С out of the reach of children.
Glucosamine is a substance produced by cartilage tissue. The lack of this component is the cause of many joint diseases. Its use in the formulations of dosage forms contributes to the effective treatment of diseases of the musculoskeletal system.
On the pharmaceutical market, the drug is provided in several forms, each of which has a similar composition, but different auxiliary components.
Dosage forms:
- pills;
- powder;
- solution.
Composition and dosage:
Tablets of 30, 60, 90 and 100 pieces in vials. 1 tablet contains:
- glucosamine sulfate - 750 mg;
- additional ingredients.
20 sachets per pack. 1 sachet of powder for solution preparation contains:
- glucosamine sulfate - 1500 mg;
- other substances.
Glucosamine in ampoules for intramuscular injection (2 ml each):
- active ingredient - 400 mg
- auxiliary components.
Pre-dilute with the supplied solvent (1 ml ampoules).
Pharmacological properties
Glucosamine is intended to restore the structure of cartilage tissue. It significantly slows down the processes of joint destruction and prevents the development of arthrosis, eliminating the accompanying pain syndromes and increasing mobility.
The drug performs the following functions:
- stimulates metabolic processes;
- fills the natural need for the content of the substance;
- provides joint permeability;
- suspends destructive processes;
- normalizes the amount of calcium in bone tissues.
Instructions for use
Treatment of joint pathologies in adults with Glucosamine is mainly performed by the oral route in the form of powder or tablets, the dosage of which is determined by the doctor.
Dosing scheme for powder form:
- 1 sachet per day (diluted in a glass of water);
- take with meals;
- duration - up to 10 weeks (depending on the stage of the disease).
Tablet system:
- 1 daily with a glass of water;
- duration - 6 months.
The effect after taking the drug is noticeable after 2 weeks, then the positive result is enhanced.
Indications for appointment
Glucosamine is a drug for the treatment of diseases of the joints and spine. It is prescribed in complex therapy for the following pathologies:
- osteochondrosis;
- osteoarthritis;
- periarthritis;
- trauma;
- progressive spondelosis.
The use of this drug allows you to eliminate the feeling of stiffness in the joints, inflammation, and relieve pain. Recommended for people who are involved in heavy sports. As a prophylaxis, the drug is indicated for people over 55 years old. Its reception significantly reduces the load on the joints, improves their mobility, and reduces the risk of developing joint pathologies.
Glucosamine for osteochondrosis
The effect of the drug in osteochondrosis of the spine is quite large: the correction of metabolic processes in the cartilaginous tissue, the reduction of the destruction process, the stimulation of metabolism, the restoration of the former functions of the joints.
Since the disease begins with pathological changes in the intervertebral cartilage, the use of Glucosamine in treatment contributes to the complete elimination of the root cause of the problem.
This drug is part of the complex therapy aimed at a speedy recovery.
Contraindications
For the treatment of joints and to eliminate problems with the spine, preparations containing glucosamine chondroitin are used. Like any drug, this remedy has contraindications, among which are:
- pregnancy and lactation period;
- impaired renal function;
- children under 15 years old;
- people who are highly sensitive to the components of the drug.
Side effects
Basically, the drug does not have complex consequences, but in some cases the following are observed:
- pain syndromes in the region of the xiphoid process;
- stool changes;
- bouts of flatulence;
- frequent headaches;
- rashes on the skin.
If such negative reactions of the body appear, it is recommended to immediately seek help from a specialist.
Interaction with other drugs
Glucosamine performs the following actions when combined with the intake of various medications:
- can significantly enhance the absorption of tetracycline drugs by the intestine;
- reduces the absorption of antibiotics;
- enhances the analgesic and anti-inflammatory effects of some non-steroidal drugs, but with simultaneous use;
- helps to reduce the negative effect of corticosteroids on cartilage tissue.
Price
Cheap Glucosamine analogues
Glucosamine, like any other drug of this type, has cheaper analogues, which have the main component in their composition:
- Artra pills;
- Honda capsules;
- Sinarta - powder for oral administration;
- Glucosate is a solution for injection.
The use of the above medications is possible only with the permission of the attending physician.
Glucosamine and Elbona - which is better?
Elbona is a modern preparation intended for the regeneration of joint tissues. Its composition contains the base agent, which contributes to the rapid recovery process of existing damage. In addition, the drug is effectively used to relieve severe pain and eliminate inflammation. With the constant use of Elbona in patients, the number of non-steroidal drugs is noticeably reduced.
Elbon's drug is prescribed for the following pathologies:
- attacks of osteoarthritis;
- osteoarthritis therapy;
- back problems;
- treatment of osteochondrosis.
It is used in complex therapy along with physiotherapy procedures and a system of proper nutrition. The drug belongs to the means of a high price category, which makes it impossible to apply it to a wide range of people. Glucosamine has the same properties, but what to choose in the treatment of joint diseases is up to the attending physician.
Don or Glucosamine - which is more effective?
Dona is the main stimulator of cartilage regeneration, has strong analgesic and anti-inflammatory properties. The active substance glucosamine sulfate helps to replenish its deficiency in the body, thereby helping to restore joint tissue.
Don is applied:
- for the prevention of osteoarthritis;
- in the treatment of periarteritis of the scapula and shoulder, chondromalacia of the patella.
The drug is quickly absorbed by the intestines, easily penetrates into the cartilage tissue of the joints. The therapeutic effect lasts up to 8 weeks.
Don is a more expensive drug, which means that it is less affordable for representatives of different social groups. Don is a structural analogue of Glucosamine, but has a higher cost.
Chondroxide or Glucosamine - what to choose for osteochondrosis?
The local drug Chondroskid has anti-inflammatory properties, has analgesic effects, and improves joint regeneration.
The active ingredient chondroitin sodium sulfate slows down the process of bone destruction, reduces calcium loss, and normalizes metabolic properties. It has anti-inflammatory properties.
It is used to treat pain syndromes in cartilage tissues with osteochondrosis and osteoarthritis, to increase joint mobility.
Chondroxide is used:
- with degenerative pathologies of the spine and joints;
- with fractures;
- to eliminate the consequences of surgical interventions.
The drug has a wide spectrum of action and is available for purchase to everyone. Chondroxide, like Glucosamine, has the ability to restore damaged cartilage tissue, but to improve the effect, doctors recommend combining both drugs.
To achieve the effect (some growth of cartilage or the suspension of its thinning) with arthrosis of stages 1-2, it is necessary to ingest a drug from a decent manufacturer with a duration of six months; at stage 3 (destruction of cartilage), its restoration is impossible, the reception is useless; external use (ointments, creams, gels) does not give a result at any stage. Best regards, the author of the site.
Preparations containing Chondroitine sulfate, ATC code M01AX25) and Glucosamine (Glucosamine, ATC code M01AX05):
| Common forms of release containing Chondroitin (CI) and Glucosamine (GA) | |||
|---|---|---|---|
| Release form | Pack., Pcs | Price, p | |
| Artra; USA, Unipharm; CHI 500mg + HA 500mg | pills | 30 | 680-1.410 |
| 60 | 1.210-2.140 | ||
| 100 | 1.730-3.000 | ||
| 120 | 1.640-3.200 | ||
| Teraflex (Teraflex); Germany, Bayer; CHI 500mg + HA 400mg | capsules | 60 | 1.000-3.655 |
| 100 | 1.630-3.000 | ||
| 200 | 3.000-4.300 | ||
| Teraflex Advance; USA, Sagmel; CHI 200mg + HA 250mg + Ibuprofen 100mg | capsules | 30 | 450-1.270 |
| 60 | 840-2.190 | ||
| 120 | 1.700-3.000 | ||
| Kondronova (Kondronova); India, Panacea; CHI 200mg + HA 250mg | capsules | 30 | 380-720 |
| Inoltra (Inholtra), dietary supplement; USA, Irwin, HI 200mg + HA 1g + omega3 700mg + Mn 1mg + vit E and C | capsules | 60 | 1.600-3.370 |
| 72 | 2.330-2.740 | ||
| 90 | 2.600-4.270 | ||
| 180 | 4.550-7.920 | ||
| Tab. "Glucosamine-Chondroitin Plus", (dietary supplement); USA, Solgar | tablets 1.750mg | 75 | 2.200-3.990 |
| Tab. "Complex of glucosamine and chondroitin", (dietary supplement); USA, Solgar | tablets 2.090mg | 60 | 2.250-3.850 |
| Doppelgerts active Glucosamine + Chondroitin (dietary supplement); Germany, Kweisser; CHI 150mg + GA 750mg | capsules | 30 | 340-695 |
| Glucosamine - chondroitins. complex, (dietary supplement); Russia, Pharmacor | capsules | 60 | 240-700 |
| 90 | 330-680 | ||
| Common forms of release containing only Chondroitin (CI) | |||
| Name, manufacturer, composition | Release form | Pack., Pcs | Price, p |
| Structum; France, Pierre Fabre; CHI 500mg | capsules | 60 | 1.250-2.310 |
| Mucosat; Russia, GIKiM | p / r for / and / m 100mg in 1ml | 5 | 320-810 |
| 10 | 625-1.120 | ||
| r / r for and i / m 200mg in 2ml | 5 | 560-1.050 | |
| 10 | 610-900 | ||
| Chondroguard Russia, Sotex | p / r for / and / m 100mg in 1ml | 10 | 670-1.320 |
| r / r for and i / m 200mg in 2ml | 10 | 1.200-2.260 | |
| Chondrolone; Russia, Microgen | pore d / and 100mg | 5 | 920-1.100 |
| 10 | 770-1.820 | ||
| Artradol; Russia, Biok | pore d / and 100mg | 10 | 560-1.080 |
| Drastop, Romania, Rompharm | r / r for and i / m 200mg in 2ml | 10 | 900-1.310 |
| Chondroitin; Russia, Vertex | capsules 250mg | 50 | 280-540 |
| Chondroitin sulfate; Russia, Ellara | pore d / and 100mg | 10 | 620-1.030 |
| capsules 250mg | 50 | 270-480 | |
| Chondroitin-Akos; Russia, Synthesis | ointment 5% 30g | 1 | 55-315 |
| Chondroitin; Russia, Vertex | gel 5% 30g | 1 | 60-220 |
| Chondroitin-Verte, Russia, Vertex | capsules 250mg | 50 and 60 | 230-510 |
| Chondroxide (Chondroxide), Russia, Nizhpharm for Shtada | gel 5% 30g | 1 | 240-600 |
| gel 5% 40g | 1 | 290-665 | |
| ointment 5% 30g | 1 | 285-655 | |
| tablets 250mg | 60 | 450-850 | |
| p / r for / and / m 100mg in 1ml | 10 | 510-860 | |
| r / r for and i / m 200mg in 2ml | 10 | 920-1.470 | |
| Chondroxide Forte; Russia, Nizhpharm (in 1g - 50mg CI and 10mg meloxicam) | cream 30g | 1 | 290-700 |
| Common forms of release containing only glucosamine (GA) | |||
| Name, manufacturer, composition | Release form | Pack., Pcs | Price, p |
| Dona, Rottafarm-Madaus | tablets 750mg | 60 | 1.200-2.265 |
| powder 1.5g | 20 | 1.040-2.050 | |
| r / r for and i / m 200mg in 2ml | 6 | 1.130-2.020 | |
| Glucosamine Maximum; Netherlands Herkel | TB weighing 1470mg | 30 | 370-750 |
| 60 | 550-920 | ||
| Elbona, Russia, Ellara | r / r for and i / m 200mg in 2ml | 6 | 960-1.485 |
| Sustagard Artro; Russia, Sotex | r / r for and i / m 200mg in 2ml | 5 | 700-1.050 |
| Sustilak, India, Medrik | tablets 1.5g | 60 | 1.050-2.200 |
| Rarely found and withdrawn from sales forms of release | |||
| Name | Release form | Packing, pcs | Price, p |
| Structum; France, Pierre Fabre, HI 250mg | capsules | 60 | 1.430-2.140 |
| Inoltra Sulfamax MSM, USA, Irvine | pills | 90 | 2.900-5.900 |
| Chondroxide Maximum, Russia, Nizhpharm | cream 8% 50g | 1 | 625-1.180 |
| Tazan, Russia, Synthesis, HI 500mg + GA 500mg | pills | 90 | 1.250-1.650 |
| Ellastanga Active Glucosamine; Russia, Dina + | gel and caps | not | |
| Artradollong (dietary supplement); Russia, Smirnov | capsules | 30 | not |
| Artrin, Russia, GIKM | ointment | 1 | not |
Teraflex (Glucosamine + Chondroitin) - official instructions for use:
Clinical and pharmacological group:
A drug that regulates the metabolism in cartilage tissue
pharmachologic effect
Stimulator of cartilage tissue regeneration.
Glucosamine hydrochloride and chondroitin sodium sulfate are involved in the biosynthesis of connective tissue, helping to prevent the destruction of cartilage and stimulating tissue regeneration. The introduction of exogenous glucosamine enhances the production of cartilage matrix and provides nonspecific protection against chemical damage to the cartilage. Another possible effect of glucosamine is the protection of damaged cartilage from metabolic destruction caused by NSAIDs and GCS, as well as its own moderate anti-inflammatory effect.
Chondroitin Sulfate Sodium serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronon, the synthesis of proteoglycans and collagen type II, and also protects hyaluronon from enzymatic degradation (by suppressing the activity of hyaluronidase); maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms and inhibits the activity of those enzymes (elastase, hyaluronidase) that break down cartilage. When treating osteoarthritis, it relieves symptoms and reduces the need for NSAIDs.
Pharmacokinetics
Glucosamine sulfate
Absorption and distribution
The oral bioavailability of glucosamine is 25% (due to the "first pass" effect through the liver).
After absorption, radioactively labeled glucosamine is first found in plasma and later penetrates into tissues. The highest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the dose taken persists for a long time in bone and muscle tissue.
Withdrawal
It is excreted mainly in the urine unchanged, partly in the feces. T1 / 2 - 68 h.
Chondroitin sulfate
Suction
Bioavailability is about 12%. With a single oral administration in a dose of 800 mg (or 400 mg 2 times a day), the plasma concentration increases over 24 hours.
Metabolism and excretion
Metabolized by desulfurization. It is excreted by the kidneys. T1 / 2 - 310 min.
Indications for the use of TERAFLEX®
- degenerative-dystrophic diseases of the joints and spine: osteoarthritis of the I-III degree, osteochondrosis.
Method of administration and dosage
For adults and children over 15 years of age, during the first three weeks, the drug is prescribed 1 capsule 3 times a day; on the following days - 1 capsule 2 times a day. Duration of treatment is 3-6 months. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.
The drug is taken orally, regardless of food intake, with a small amount of water.
Side effect
From the digestive system: epigastric pain, flatulence, diarrhea, constipation.
From the side of the central nervous system: dizziness, headache, drowsiness, insomnia.
Others: tachycardia, peripheral edema, leg pain, allergic reactions.
Contraindications to the use of TERAFLEX®
- severe renal failure;
- pregnancy;
- lactation period (breastfeeding);
- age up to 15 years;
- hypersensitivity to the components of the drug.
With caution, the drug should be prescribed for diabetes mellitus, a tendency to bleeding, bronchial asthma.
Use of the TERAFLEX® drug during pregnancy and breastfeeding
There are no clinical data on the efficacy and safety of using Teraflex® during pregnancy and during breastfeeding.
Application for impaired renal function
Contraindicated in severe renal impairment.
special instructions
In the event of adverse reactions from the digestive system, the dose of the drug should be reduced by 2 times, and in the absence of improvement, the drug should be canceled.
Teraflex® can be used in combination therapy with GCS and NSAIDs.
Overdose
To date, cases of overdose of Teraflex® have not been described. In case of an overdose, the following symptoms are possible: hemorrhagic rash, nausea, vomiting.
Treatment: gastric lavage, symptomatic therapy.
Drug interactions
Increases the absorption of tetracyclines.
Reduces the action of semi-synthetic penicillins and chloramphenicol.
Chondroitin sulfate enhances the effect of anticoagulants.
Terms of dispensing from pharmacies
The drug is approved for use as a means of OTC.
Storage conditions and periods
The drug should be stored in a dry place out of the reach of children at a temperature not exceeding 25 ° C. Shelf life is 3 years.
