L methionine what. How to take the amino acid methionine? Instructions for use. What is S-adenosyl methionine

L-Methionine - aliphatic essential amino acid. Methionine is part of proteins.
Methionine also serves in the body as a donor of methyl groups (as part of S-adenosyl-methionine) during the biosynthesis of choline, adrenaline, etc., as well as a source of sulfur during the biosynthesis of cysteine. Synthetic methionine is used to enrich feed and food.
The pharmacological preparation of methionine has a lipotropic effect, increases the synthesis of choline, lecithin and other phospholipids, to some extent helps reduce cholesterol in the blood and improve the phospholipid/cholesterol ratio, reduce the deposition of neutral fat in the liver and improve liver function, and may have a moderate antidepressant effect (according to -apparently due to the effect on the biosynthesis of adrenaline).
S-adenosyl-methionine (SAMe, heptral) has a stronger positive effect on liver function and a more pronounced antidepressant effect than methionine.
Methyl-methionine-sulfonium (in pharmacology known as “methiosulfonium chloride”), or “vitamin U”, has a pronounced cytoprotective effect on the mucous membrane of the stomach and duodenum, promotes the healing of ulcerative and erosive lesions of the mucous membrane of the stomach and duodenum.

Indications for use

Capsules L-Methionine recommended for use in the following diseases:
- Hepatitis, cirrhosis, dystrophy and toxic liver damage, Gilbert's syndrome, cholelithiasis, liver dysfunction.
- Poisoning, when large amounts of glutathione are required to neutralize toxins and protect the liver.
- Toxicosis of pregnancy.
- Deterioration and hair loss, brittle nails, early skin aging.
- Depression, chronic fatigue syndrome.
- Atherosclerosis.
- Parkinson's disease.
- Prevention of urinary tract infections. Cystitis, especially in young women, who suffer from it much more regularly than other segments of the population.
- Alzheimer's disease.
- Alcoholism.
- Obesity, diabetes.
- Women who use oral contraceptives or take estrogen-containing medications.
- In sports nutrition, including weightlifting, to accelerate recovery processes after training and wound healing.

Mode of application:
L-Methionine Take 2 capsules daily 1-3 times as needed, preferably on an empty stomach.

Side effects:
When taking capsules L-Methionine The following side effects may occur: very rarely - allergic reactions, nausea, vomiting.

Contraindications

.
Taking capsules is contraindicated L-Methionine in case of individual intolerance to the components of the drug.

Storage conditions

Keep out of the reach of children.

Release form

L-Methionine- gelatin capsules 500 mg; 100 pieces. packaged.

Compound

:
1 capsule L-Methionine contains:
Vitamin B-6 (pyridoxine chloride) 10 mg
L-methionine (free form) 500 mg
Other ingredients: gelatin (capsules), magnesium stearate (vegetable source), silicon dioxide.

Additionally

:
Methionine is necessary for normal development of the nervous system. If it is deficient during pregnancy, infants may have neural tube defects (spina bifida - incomplete closure of the neural tube).
Vegetarians are more susceptible to methionine deficiency than those who consume meat products.
Don't take too much methionine if you eat a lot of meat. With an excess of methionine and a deficiency of vitamins B6 and folic acid, methionine in the body is converted into homocysteine, which worsens the condition of heart disease. If you take too much L-methionine, supplemental vitamin B6 and folic acid are necessary.

Main settings

Name:	L-METHIONINE

An essential aliphatic sulfur-containing substance that is vital for human health. Methionine is not synthesized in the human body and therefore the only natural way to replenish reserves of this amino acid is a diet containing foods rich in methionine.
If there is a deficiency of methionine in the human body, it is possible to take methionine as an amino acid supplement or therapy that involves intravenous administration of the pharmacological drug methionine.

What is S-adenosyl methionine?

In the liver, methionine is metabolized into S-adenosyl methionine(ademetionine, SAMe, heptral, heptor). Under ideal conditions, the liver produces at least 8 grams of S-adenosyl methionine every day.
S-adenosyl methionine has a stronger positive effect on liver function and a more pronounced antidepressant effect than methionine. The methyl group (CH3) of S-adenosyl methionine makes it reactive. More than forty metabolic reactions require the transfer of a methyl group from S-adenosyl methionine to substrates such as nucleic acids, proteins and lipids.
In pharmacology, S-adenosyl methionine is used as a stimulator of liver regeneration, an antifibrotic, an anticholestatic, and an antidepressant. The experiment demonstrated the antifibrotic (anti-scarring) activity of ademetionine.
S-adenosyl methionine is sold as a supplement in the United States, typically under the name SAMe. It is also sold as a medicine in Russia and Italy, under the brand names Gumbaral ® and Samyr ®.

What are the benefits of methionine?

Methionine alleviates, helps treat inflammation, liver diseases, and relieve some muscle pain.
Methionine is beneficial for people who suffer from estrogen dominance, where the amount of estrogen in the body is too high compared to the hormone progesterone. Methionine converts the more active and carcinogenic estradiol into estriol (the “good” estrogen).
Methionine and its metabolite, S-Adenosyl methionine, have anti-inflammatory effects and, therefore, can be used in combination to treat osteoarthritis, as well as to combat hepatitis and cirrhosis. Methionine derivatives may be beneficial for multiple sclerosis, fibromyalgia, and chronic fatigue.
Methionine helps remove heavy metals from the body, which has a beneficial effect on the health of the liver, kidneys and bladder. This amino acid supports artery function and maintains healthy nails, hair and skin. In addition, methionine is of great importance for the growth of muscle mass and energy.

Functions of methionine in the body

One of the important functions of methionine is its ability to be a supplier of sulfur to other compounds that the body needs for normal metabolism and growth (in particular, methionine is a source of sulfur in the biosynthesis of cysteine). Sulfur is a key element - without enough sulfur, the body is unable to participate in necessary chemical and metabolic reactions and use sufficient antioxidants.
Methionine also serves as a donor of methyl groups in the body (as part of S-adenosyl-methionine) during the biosynthesis of choline and adrenaline.
Methionine belongs to a group of so-called lipotropic compounds that help the liver process fat in the body.
Methionine is essential for the formation of healthy collagen and improves the tone and flexibility of hair, skin and nails.
Methionine is involved in the formation of complex compounds - chelates of heavy metals, which helps remove them from the body.
Methionine helps prevent premature ejaculation.
Methionine reduces the level of free histamine in the body. In various pathological processes, histamine, which is usually found in the body predominantly in a bound, inactive state, turns into free, highly active histamine. It causes spasm of smooth muscles (including bronchial muscles), dilation of capillaries and a decrease in blood pressure; stagnation of blood in the capillaries and increased permeability of their walls, causing swelling of the surrounding tissues and thickening of the blood. Due to reflex stimulation of the adrenal medulla, adrenaline is released, arterioles narrow and heart contractions increase. Histamine causes increased secretion of gastric juice.
Due to its influence on the biosynthesis of adrenaline, methionine has a moderate antidepressant effect and helps prevent chronic depression.
Methionine is useful in treating urinary tract infections as it stops bacteria from sticking to proliferate and in the walls of the urinary tract.

Sources of methionine

Sources of methionine include protein-rich foods like eggs, fish, dairy products and Brazil nuts, as well as grains.

Raw salmon fillet – 626 mg

Raw pork – 554 mg
Raw chicken fillet – 552 mg
Chicken egg – 380 mg

Methionine supplements

Most healthy people do not require methionine supplements. However, for true vegetarians and those following a low-protein diet, taking dietary methionine supplements is recommended. If methionine supplementation is not required, taurine, cysteine and other sulfur-containing amino acids, as well as vitamins and B9 () should also be included in the diet.
The recommended dosage for a methionine supplement is 200 mg to 1000 mg in divided doses throughout the day.

Methionine deficiency

Maintaining adequate levels of methionine in the body helps ensure overall good health, and conversely, methionine deficiency can cause side effects:
Liver damage, swelling and hair breakage.
Low methionine levels can slow the normal growth and development of children and pregnant women.
Methionine deficiency can lead to neural tube defects in children. This is one of the causes leading to myelomeningocele (spina bifida).
Methionine deficiency can also lead to severe mental disorders.

Use of methionine preparations

The most common medical use of the amino acid methionine is as a preventative treatment for liver damage resulting from paracetamol (acetaminophen) poisoning.
Paracetamol- a popular medicine that also has an antipyretic effect, as a rule, it is dispensed without a doctor’s prescription. Large amounts of paracetamol can cause serious liver damage. For example, a single dose of paracetamol in a dose of more than 10 g in adults or more than 140 mg/kg in children leads to poisoning, accompanied by severe liver damage.
In cases of poisoning (within 10 hours of overdose), methionine is taken orally or administered intravenously to prevent liver damage.

Methionine is used to increase protein levels in vegetarians and vegans who are not getting enough protein due to their diet. Methionine is beneficial for those who metabolize large amounts of protein (such as athletes) and is often recommended as a protein replacement for people who are considered heavy drinkers.
Taking methionine medications can have positive effects in patients suffering from adult attention deficit hyperactivity disorder (ADHD), as well as fibromyalgia.

In addition, methionine reduces histamine levels in the body, causing the nervous system to work properly, activating memory. Histamine acts as neurotransmitters, so problems with histamine levels can affect nerve function throughout the body. Histamine can cause allergic reactions and dilates blood vessels, affecting the brain's sending and receiving of messages. As a result, methionine supplements are sometimes given to patients with Parkinson's disease and.

In veterinary medicine, methionine is popular as an organic feed additive for birds.
Methionine is used as an ingredient in some commercial pet foods and neutralizes ammonia in urine, lowering its pH so it does not harm the grass.

Side effects of methionine and precautions

Although methionine rarely causes any adverse symptoms when used correctly, allergic reactions and other side effects are possible, regardless of the form in which it is administered to the body. The most common side effects are nausea and vomiting. Some people feel drowsy after taking methionine medications.
If a person shows severe signs of an allergic reaction, such as rash, hives, difficulty breathing, chest tightness, and swelling in the neck, emergency medical attention is needed.
Pregnant women and nursing mothers should not take methionine supplements without first consulting a doctor because it is not clear how methionine supplements affect the infant. Those taking oral contraceptives should also inform healthcare professionals before using methionine, as it increases estrogen production. The amino acid methionine may worsen symptoms of liver disease, acidosis, atherosclerosis, and the genetic condition methylenetetrahydrofolate reductase (schizophrenia).
Patients with serious liver disease or elevated stomach acid levels are generally not recommended to take methionine supplements.

Despite the fact that the amino acid methionine is found in foods such as sesame, fish, grains, in the form of a dietary supplement it is a much more powerful drug. To avoid the most dangerous side effects of methionine, it is important to consult with your doctor to find out the correct dosage for the condition being treated. As practice shows, serious side effects of methionine are often the result of the patient taking an excessive amount of this substance.
Taking large amounts of methionine supplements can cause permanent brain damage, cause symptoms of schizophrenia (confusion, agitation, and delirium), stimulate tumor growth, increase homocysteine levels in the blood, and increase the risk of heart attack.
In rare cases, when combined with other medications, S-adenosyl methionine may lead to overproduction of the neurotransmitter serotonin (“serotonin storm”). At least one such case with a fatal outcome is known.

Excipients: potato starch 44 mg, methylcellulose 3 mg, stearic acid 3 mg, wheat flour 18.556 mg, sucrose 62.486 mg, magnesium carbonate 18.264 mg, talc 0.496 mg, refined sunflower oil 0.097 mg, beeswax 0.097 mg, azorubine dye 0.004 mg .

10 pieces. - contour cellular packaging.
10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.

pharmachologic effect

An essential amino acid, a donor of mobile methyl groups for the synthesis of choline and phospholipids, the implementation of a lipotropic effect. Participates in the synthesis of adrenaline, proteins, remethylation reactions, deamination, decarboxylation, etc. Participates in the metabolism of sulfur-containing amino acids, adrenaline, creatinine, cyanocobalamin, ascorbic acid, hormones, and enzymes. Has a detoxifying effect. Has a metabolic, hepatoprotective effect. Easily absorbed in the intestines, excreted in urine in small quantities.

Indications

Liver diseases (hepatosis, cirrhosis), occurring with fatty infiltration of hepatocytes; prevention of toxic liver damage from arsenic, chloroform, benzene, alcohol; protein deficiency of various origins as part of combination therapy.

Contraindications

Viral hepatitis, severe hepatic encephalopathy, hypersensitivity to the components of the drug. The drug is contraindicated in children under 6 years of age.

Carefully. Renal failure (risk of increased hyperazotemia) Taking Methionine for viral hepatitis is not recommended.

Dosage

Side effects

Overdose

Symptoms: decreased blood pressure, tachycardia, disorientation.

Treatment is symptomatic.

special instructions

The drug should be prescribed in a balanced ratio with other amino acids. Unbalanced use of methionine in large doses can have a damaging effect on the cells of the liver and other organs. The drug does not affect the ability to drive a car or engage in potentially hazardous activities that require increased attention and speed of mental and motor reactions.

Methionine is classified as an essential sulfur-containing amino acid with an unpleasant odor that cannot be produced by the body itself.

The source of the substance is dairy and other food products containing casein. In addition, there are drugs similar to natural methionine, usually used in sports nutrition. This aliphatic sulfur-containing amino acid plays an important role in protein synthesis and has fat-soluble properties, which allows it to prevent lipid deposition in the liver.

Functions in the body

Methionine is a precursor to cysteine and taurine, as it is important in the synthesis of these substances. It is also known for its antioxidant properties, making it an excellent defender against free radicals and toxins. The amino acid reacts with harmful substances, protecting cells from destruction, and helps cleanse the body of toxins and heavy metals. With a deficiency of this useful substance, the body loses its ability to cleanse itself, and swelling appears caused by excess fluid in the tissues.

Has your hair started to fall out, and your chances of developing atherosclerosis have increased sharply? Most likely, the body does not have enough methionine. Being the basis for proteins and hormones (for example, adrenaline, choline, melatonin), methionine influences many vital processes in the body. And even energy metabolism and transport of polyunsaturated fatty acids across the mitochondrial membrane also depend on this amino acid. It is a necessary element for the body's proper sleep-wake cycle. In addition to all of the above, it helps reduce the level of histamine in the blood, which allows methionine to “tame” allergic reactions.

Urinary tract

Research conducted in 2002 showed that consuming methionine can have a positive effect on urinary tract health. In particular, the substance is an excellent prophylactic against infections, as well as an effective medicine for recurrent cystitis in women. When metabolized, methionine combines with sulfuric acid, causing the kidneys to use the amino acid to acidify urine, making methionine important in the treatment of certain diseases. For example, it helps prevent the formation of kidney stones, optimize the effect of antibiotics, or inhibit the growth of bacteria in cystitis, since most microorganisms are not able to survive in an acidic environment.

In addition to all of the above, methionine affects...

…mood

Often, treatment programs for depression and Parkinson's disease contain recommendations for taking higher doses of methionine, which is involved in metabolic processes in the brain. By promoting the production of the “happiness hormone” serotonin, it improves the mood of patients and makes them more active. Maintaining adequate levels of amino acids helps to get rid of mood swings, tremors, and restless sleep. Methionine-based drugs are used to treat degenerative neurological diseases.

...cartilage

Cartilage tissue cannot fully perform its assigned functions if there is a lack of sulfur. In people suffering from arthritis, cartilage contains approximately 3 times less sulfur than in the tissues of a healthy person. In such cases, a sulfur-containing amino acid comes to the rescue. It, in combination with affects diseased cartilage as an anti-inflammatory and analgesic. In addition, it stimulates the formation of healthy cartilage tissue.

...nails and hair

In 2006, at a conference of dermatologists in Florence, the results of another study were announced: methionine strengthens the structure of nails and hair. It turned out that people who monitor the amount of amino acids and vitamins they consume have much more healthy hair than those who do not pay attention to their diet.

Other properties of methionine:

protects the liver from toxins;
increases the acidity of urine;
has a positive effect on the immune system;
slows down the accumulation of excess fat;
promotes wound healing, prevents skin and nail diseases;
effective in treating depression, alcoholism, allergies, asthma, Parkinson's disease;
facilitates detoxification in case of copper poisoning;
promotes the removal of drugs from the body;
reduces side effects from radiation exposure;
prevents improper formation of the nervous system in the fetus.

Daily requirement

There are several assumptions about what the correct daily intake of methionine should be. According to one theory, the usual daily dose for adults is determined in the proportion: 19 mg of the substance per 1 kg of weight. Others recommend taking approximately 730 mg of the amino acid per day. The third group of scientists convinces that the body’s daily need for methionine is 1-3 grams, although they will clarify: this figure may vary depending on certain factors. For example, allergies, liver disease or urinary tract infections slightly increase the body's need for methionine. At the same time, a deficiency of the substance can aggravate an allergic condition, depression, and lead to an excess of toxins. Methionine also helps against hair loss and strengthens nails. And its deficiency is fraught with anemia, steatohepatitis (inflammation of the liver), early gray hair and even an increased risk of cancer.

Who needs dose adjustment

There are conditions when the body not only needs to receive the usual daily dose of methionine, but due to some physiological processes it requires a little more. Typically, an increase in the dose of amino acid is necessary after poisoning with “chemicals” or alcohol, after illnesses that have weakened the immune system. Multiple sclerosis, diabetes, Parkinson's disease, Alzheimer's disease, mastopathy, some disorders of the liver or gallbladder, arthritis, obesity - considerable reserves of methionine will also be needed to combat these ailments.

You should not neglect foods rich in amino acids during pregnancy, since the formation of the nervous system of the unborn child directly depends on this substance. Hepatitis A, high cholesterol, some cardiac diseases and chronic liver failure, on the contrary, are a serious signal that methionine should not be abused.

Dangers of methionine deficiency

Acute deficiency of sulfur-containing amino acids causes severe mental disorders.

In addition, the body that receives insufficient amounts of methionine, as a rule, will “tell” about this in the form of edema, brittle hair, and liver disease. In children, deficiency of the substance causes delayed development and improper formation of the nervous system.

Excess: what is dangerous?

The first thing that is important to know about excess methionine is that it aggravates heart and liver diseases and aggravates atherosclerosis. Also, excessive consumption of foods rich in amino acids is prohibited for people with high stomach acidity.

Signs of intoxication caused by methionine are allergies, drowsiness, nausea, and vomiting.

Methionine in food

Since this cannot be produced by the body on its own, it must be supplied through food. In this case, the main attention is focused on protein foods containing the highest concentrations of amino acids. But given that methionine easily dissolves in an aqueous environment, you should not soak or cook foods that should serve as its source for too long. High temperatures during cooking have a detrimental effect on the amino acid - even to the point of complete destruction.

The following products can also satisfy the need for amino acids:

Brazil nut (contains 1124 mg of methionine per 100 g of product);
beef, lamb (981 mg/100 g);
parmesan (958 mg/100 g);
turkey, chicken (925 mg/100 g);
pork (854 mg/100 g);
tuna (835 mg/100 g);
raw salmon (625 mg/100 g);
sesame seeds (586 mg/100 g);
beef (554 mg/100 g);
chicken fillet (552 mg/100 g);
soybeans (547 mg/100 g);
soybean (534 mg/100 g);
hard-boiled eggs (392 mg/100 g);
yogurt (169 mg/100 g);
beans (149 mg/100 g).

Green vegetables such as Brussels sprouts and spinach can also significantly replenish amino acid stores. High levels of the substance are found in nuts, beef, lamb, cheese, turkey, pork, shellfish, soy, eggs, legumes, and dairy products. But for those who want to build muscle mass, it is important to get amino acids from animal foods.

Lovers of sesame seeds, pumpkin seeds, sunflower seeds, pistachios and cashew nuts can also rest assured about their methionine levels. 100 grams of these products contain from 30 to 13 percent of the recommended daily intake. But meat eaters with a similar portion receive the amino acid in quantities even exceeding the daily minimum. In addition to Parmesan, which is undoubtedly the leader in the cheese environment in terms of methionine content, other varieties of the product also provide amino acids. For example: Swiss, mozzarella, low-fat cottage cheese and hard goat cheese. Dishes made from salmon, mackerel, halibut, mullet, sea bass, as well as shrimp, mussels, crayfish and crabs will also help increase the level of methionine in the blood.

Interaction with other substances

Methionine is an important element in the production of various enzymes.

At the body level, it actively interacts with lipids and proteins. It is worth considering that the combination of methionine with oral contraceptives, as a rule, activates the production of the hormone estrogen. And taken together with ampicillin or any other antibiotics, it enhances their effect on the body.

Methionine is an essential sulfur-containing amino acid that is of great importance for humans as a substance that affects many vital processes. Methionine helps cleanse the body of toxins and heavy metals, protects the urinary system from infections, reduces symptoms of depression and Parkinson's disease, improving the quality of life of patients. Well, like all amino acids, they are “building materials” for proteins, on which, without exaggeration, human life depends. Don't neglect methionine! Moreover, now you know for sure what products to look for it in and how it is useful.

The page contains instructions for use L methionine. It is available in various dosage forms of the drug (250 mg tablets), and also has a number of analogues. This abstract has been verified by experts. Leave your feedback on the use of L methionine, which will help other site visitors. The drug is used for various diseases (hepatitis, hepatosis, liver cirrhosis, alcohol poisoning and other poisons). The product has a number of side effects and interactions with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the medicine during pregnancy and breastfeeding. Treatment with L methionine should only be prescribed by a qualified physician. The duration of therapy may vary and depends on the specific disease.

Instructions for use and dosage regimen

Adults - 500 mg-1500 mg 3-4 times a day.

Single doses for children under 1 year of age - 100 mg, at the age of 1-2 years - 200 mg, at the age of 3-4 years - 250 mg, at the age of 5-6 years - 300 mg, at the age of over 7 years - 500 mg; frequency of administration - 3-4 times a day.

Take 1/2-1 hour before meals. The course of treatment is 10-30 days or 10 days with 10-day breaks.

Release forms

Tablets 250 mg.

L methionine- an essential amino acid necessary to maintain growth and nitrogen balance in the body. Contains a methyl group, which is involved in the process of remethylation and is necessary for the synthesis of choline. Due to this, it normalizes the synthesis of phospholipids from fats and reduces the deposition of neutral fat in the liver.

Participates in the metabolism of sulfur-containing amino acids, in the synthesis of epinephrine, creatinine and other biologically active substances, activates the action of hormones, vitamins (B12, ascorbic, folic acids), enzymes, proteins, remethylation reactions, deamination, decarboxylation. Essential for detoxification of xenobiotics.

In atherosclerosis, it reduces the concentration of cholesterol and increases the concentration of blood phospholipids.

Indications

Liver diseases occurring with fatty infiltration of hepatocytes:

toxic hepatitis;
hepatosis (including alcoholic);
cirrhosis;
liver dystrophy;
intoxication.

As part of combination therapy:

protein deficiency of various origins;
atherosclerosis;
diabetes.

Prevention of toxic liver damage from arsenic, chloroform, benzene, alcohol.

Contraindications

hypersensitivity to methionine;
severe liver failure;
hepatic encephalopathy;
viral hepatitis.

special instructions

Use with caution in renal failure (risk of increased hyperazotemia).

When using methionine in patients with atherosclerosis, a decrease in blood cholesterol levels and an increase in phospholipid levels were noted.

Should be prescribed in balance with other amino acids. Unbalanced use of methionine in large doses can have a damaging effect on the cells of the liver and other organs.

Side effect