Calcemin ® Advance. Calcemin Advance contraindications side effects. Calcemin Advance - complex for strengthening bone tissue Calcemin Advance instructions for use

Calcemin Advance is a combined preparation that regulates the exchange of phosphorus and calcium in the body, and compensates for the lack of certain vitamins, macroelements and microelements.

Release form and composition

The drug is available in the form of film-coated tablets: pink, oval, biconvex, on one side with a dividing line (30, 60 and 120 pcs. In high density polyethylene bottles; in a cardboard box one bottle and instructions for the use of Calcemin Advance) ...

Composition of active ingredients for 1 tablet:

vitamin D 3 - 200 IU;
calcium (in the form of calcium carbonate and calcium citrate) - 500 mg;
manganese (in the form of manganese sulfate) - 1.8 mg;
magnesium (as magnesium oxide) 40 mg
copper (in the form of copper oxide) - 1 mg;
boron (in the form of sodium borate decahydrate) - 0.25 mg;
zinc (as zinc oxide) 7.5 mg

Auxiliary components:

core: croscarmellose sodium, soy polysaccharide, maltodextrin, stearic acid, sodium lauryl sulfate, microcrystalline cellulose;
shell: magnesium silicate, hypromellose, mineral oil, titanium dioxide, sunset yellow dye, triacetin, charming red dye, brilliant blue dye.

Pharmacological properties

Pharmacodynamics

Calcemin Advance contains 2 macroelements (calcium and magnesium), 4 microelements (boron, zinc, copper and manganese) and vitamin D 3 (colecalciferol). These nutrients are essential for normal body function and perform the following functions:

calcium: takes part in the formation of bone tissue, increases its density and reduces resorption; strengthens joints and bone tissue; prevents the development of diseases of the musculoskeletal system;
magnesium: participates in protein synthesis and the formation of bone and muscle tissue;
boron: improves calcium absorption; prevents the development of osteoporosis; reduces excessive activity of PTH (parathyroid hormone); reduces the risk of developing a lack of vitamin D 3;
zinc: it is necessary for the synthesis of female and male sex hormones, which has a beneficial effect on bone tissue and prevents its destruction and loss of density;
copper: takes part in the synthesis of elastin and collagen, which are part of the connective and bone tissue, which, in turn, affects the formation of bone mass;
manganese: essential for the synthesis of proteoglycans, which improve the quality of bone tissue and participate in the formation of the collagen matrix of bone tissue;
vitamin D 3: the main element that regulates the exchange of phosphorus and calcium; enhances intestinal absorption of calcium and renal reabsorption of phosphorus; essential for maintaining bone structure and skeletal formation.

Due to the special form of calcium in the preparation (calcium citrate), the best absorption of this macroelement is ensured, regardless of the state of the gastrointestinal tract. That is why Calcemin Advance can be used in patients with reduced secretory function of the digestive tract, as well as simultaneously with other drugs that reduce secretion. In addition, calcium citrate does not increase urinary calcium and oxalate levels and therefore does not lead to kidney stones. This form of calcium does not interfere with the absorption of iron, thereby reducing the risk of iron deficiency anemia.

Pharmacokinetics

Information on the pharmacokinetic parameters of Calcemin Advance is not provided.

Indications for use

Calcemin Advance is used in diseases of the musculoskeletal system (in order to improve the healing of traumatic fractures), for the prevention and complex therapy of osteoporosis of various origins (in particular, in women during surgical and natural menopause, as well as in patients who take immunosuppressants and glucocorticosteroids) and to compensate for the lack of macro- and micronutrients in adolescents.

Contraindications

Absolute:

active tuberculosis;
severe renal failure;
urolithiasis disease;
an increase in the content of calcium in the urine;
Benier-Beck-Schaumann disease (sarcoidosis);
vitamin D hypervitaminosis;
high concentration of calcium in blood plasma;
allergy to soy and peanut butter (since the tablets contain soy polysaccharide);
children under 12 years of age;
hypersensitivity to the ingredients of the drug.

Relative (Calcemin Advance tablets are used with caution):

mild to moderate renal impairment;
period of pregnancy;
breast-feeding.

Calcemin Advance: instructions for use (dosage and method)

Calcemin Advance tablets are taken orally with water (with meals).

improvement of fracture healing: one tablet once a day for 1–1.5 months;
complex treatment of osteoporosis: one tablet twice a day for 3 months;
prevention of osteoporosis: one tablet once a day for 2 months;
lack of macro- and microelements (children over 12 years old): one tablet once a day for 1-1.5 months.

Side effects

While taking Calcemin Advance, there may be side reactions from the gastrointestinal tract (vomiting and nausea, constipation, flatulence, loose stools), metabolism (increased concentration of calcium in blood plasma and urine), as well as allergic reactions in the form of itching, urticaria and skin rashes.

Overdose

Taking high doses of Calcemin Advance and / or long-term treatment can lead to an overdose, manifested by vitamin D 3 hypervitaminosis, hypercalciuria and hypercalcemia. The main symptoms of an overdose: thirst, decreased appetite, dizziness, nausea, headache, vomiting, fainting, muscle weakness, abdominal pain, constipation, urolithiasis, bone pain, nephrocalcinosis, polyuria, mental disorders, fatigue, coma; in severe cases, arrhythmias. Long-term intake of calcium in a daily dose of more than 2500 mg can lead to soft tissue calcification and kidney damage.

At the first sign of an overdose, you should reduce the dose of the drug or cancel it completely, and then consult a doctor. It is possible to carry out symptomatic therapy and standard measures to prevent intoxication (gastric lavage, induction of vomiting).

Patients with hypercalciuria (more than 300 mg per day) are prescribed loop diuretics, calcitonin, glucocorticosteroids, bisphosphonates, rehydration, and in severe cases, hemodialysis.

special instructions

Calcemin Advance should be taken in doses prescribed by your doctor or indicated in the instructions. Excessive intake of calcium into the body can lead to impaired absorption of zinc, iron and other vital minerals.

Influence on the ability to drive vehicles and complex mechanisms

There are no data on the effect of Calcemin Advance on the reaction rate and concentration of attention when driving a car and other vehicles and mechanisms.

Application during pregnancy and lactation

Calcemin Advance can be used during pregnancy and lactation, but only after consulting a doctor.

Pregnant women should not receive more than 600 IU of vitamin D 3 and 1500 mg of calcium per day, as hypercalcemia can cause defects in the physical and mental development of the fetus.

Colecalciferol, as well as its metabolites, are secreted into breast milk, which must be taken into account when supplementing vitamin D 3 and calcium with a breastfed baby.

Childhood use

Calcemin Advance is contraindicated in children under 12 years of age.

With impaired renal function

The drug should not be used in case of urolithiasis and severe renal failure.

In the case of mild and moderate renal failure, Calcemin Advance is used with caution.

Drug interactions

With the joint use of Calcemin Advance with other drugs, the following drug interactions are possible:

vitamin A: the toxicity of vitamin D 3 is reduced;
cardiac glycosides: the toxicity of cardiac glycosides increases (it is necessary to monitor the electrocardiogram and the patient's clinical condition);
laxatives: absorption of vitamin D 3 decreases;
diuretics from the thiazide group: the risk of hypercalcemia increases;
loop diuretics (eg furosemide): increased renal excretion of calcium;
barbiturates, glucocorticosteroids and phenytoin: the effectiveness of vitamin D 3 decreases;
levothyroxine, hormonal contraceptives for oral administration, glucocorticosteroids: absorption of calcium ions decreases;
antacids containing aluminum: the effectiveness of Calcemin Advance decreases.

Calcemin Advance is not recommended to be taken simultaneously with tetracycline antibiotics (the interval between taking these drugs should be at least 3 hours), sodium fluoride and bisphosphonates (the interval should be at least 2 hours).

Calcemin Advance should not be combined with calcium channel blockers.

Analogs

Calcemin Advance analogs are Calcium D3 Nycomed, Vitrum Calcium with vitamin D3, Calcemin Silver, Osteokea, etc.

Terms and conditions of storage

Keep out of the reach of children at a temperature not exceeding 25 ° C. Protect from moisture.

The shelf life is 3 years.

Contract Pharmacal Corporation Sagmel Inc.

Country of origin

UNITED STATES OF THE USA

Product group

Vitamin complexes

Calcium-phosphorus metabolism regulator.

Forms of issue

Film-coated tablets - 120 pcs per pack. Film-coated tablets - 30 pcs per pack. Film-coated tablets - 60 pcs per pack.

Description of the dosage form

Tablets are biconvex oval, film-coated pink with a line on one side. Tablets are biconvex oval, film-coated pink with a line on one side. Tablets are biconvex oval, film-coated pink with a line on one side.

pharmachologic effect

Combined preparation containing vitamins, micro- and macroelements; the action is due to the properties that make up the ingredients. Calcium is involved in the formation of bone tissue, reduces resorption (resorption) and increases bone density, prevents diseases of the musculoskeletal system, helps to strengthen the skeletal system and joints. Calcium citrate ensures the absorption of calcium, regardless of the functional state of the gastrointestinal tract, which is applicable for the treatment of patients with reduced secretory function of the gastrointestinal tract, as well as during treatment with drugs to reduce secretion; reduces the level of markers of bone resorption, which indicates a slowdown in the processes of destruction of bone tissue; regulates the level of parathyroid hormone, which leads to an improvement in the regulation of calcium homeostasis; does not increase the content of oxalates and calcium in the urine, therefore does not cause the risk of night stones formation; does not block the absorption of iron, which reduces the risk of developing iron deficiency anemia. Colecalciferol (vitamin D3) regulates the exchange of calcium and phosphorus in the body, participates in the formation of the bone skeleton. promotes the preservation of bone structure, enhances the absorption of calcium in the intestine and the reabsorption of phosphorus in the renal tubules. Magnesium is involved in the formation of muscle and bone tissue, and also takes part in protein synthesis (including type I collagen). Zinc and magnesium are essential for the synthesis of organic bone matrix. Zinc promotes the synthesis of sex hormones, which prevents the destruction of bone tissue. It has a beneficial effect on bone density. Manganese is involved in the formation of proteoglycaia, which improves the quality of bone tissue and forms the protein (collagen) matrix of bone tissue. Copper is involved in the synthesis of collagen and elastin, which is part of bone and connective tissue, which affects the formation of bone mass. Boron reduces the excessive activity of parathyroid hormone, improves calcium absorption, reduces the risk of developing cholecalciferol deficiency, and helps prevent osteoporosis.

Special conditions

Application during pregnancy and breastfeeding During pregnancy and breastfeeding, consult your doctor about taking the drug. The daily dose for pregnant women should not exceed 1500 mg of calcium and 600 IU of vitamin D3, since hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the mental and physical development of the child. In lactating women, it should be borne in mind that cholecalciferol and its metabolites pass into breast milk. This should be taken into account when adding calcium and vitamin D3 to a child. The dose should not exceed that indicated in the instructions, since an increased intake of calcium can inhibit the absorption of iron, zinc and other essential minerals in the intestine. Influence on the ability to drive a car and driving mechanisms There are no data on the effect of the drug on the speed of psychomotor reactions when driving a car and working with precise mechanisms.

Compound

Calcium (calcium citrate and calcium carbonate) 500 mg Colecalciferol (vit.D3) 200 IU Magnesium (in the form of oxide) 40 mg Zinc (in the form of oxide) 7.5 mg Copper (in the form of oxide) 1 mg Manganese (in the form of sulfate) 1.8 mg Boron (in the form of sodium borate) 250 μg Excipients: maltodextrin, microcrystalline cellulose, croscarmellose sodium, acacia, stearic acid, soy polysaccharide, titanium dioxide, sodium lauryl sulfate. Shell composition: hypromellose (hydroxypropyl methylcellulose), magnesium silicate, triacetin, mineral oil, FD&C red lacquer No. 40, FD&C yellow lacquer No. 6, FD&C blue lacquer No. 1.

Calcemin Advance indications for use

Prevention and complex treatment of osteoporosis of various origins: - in women during menopause (natural and surgical); - in persons taking glucocorticosteroids and immunosuppressants for a long time. Therapy of diseases of the musculoskeletal system: to improve the consolidation of traumatic fractures. To replenish the deficiency of calcium and trace elements in adolescents.

Calcemin Advance contraindications

- urolithiasis disease; - hypercalcemia; - hypercalciuria; - children under 12 years old; - hypersensitivity to the components of the drug.

Calcemin Advance side effects

Nausea, vomiting, flatulence, diarrhea, constipation, hypercalcemia and hypercalciuria, allergic reactions (pruritus, rash, urticaria).

Drug interactions

With the simultaneous use of the drug Calcemin® Advance with vitamin A, the toxicity of vitamin D3 decreases. Phenytoin, barbiturates, glucocorticoids reduce the effectiveness of vitamin D3. Laxatives reduce the absorption of vitamin D3. Glucocorticoids, hormonal contraceptives for systemic use, levothyroxine reduce the absorption of calcium ions. With the simultaneous use of tetracyclines, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is disturbed) - at least 2 hours. With the simultaneous use of the drug Calcemin® Advance with cardiac glycosides, their toxicity increases (monitoring of the ECG and the clinical state is necessary), with thiazide diuretics - the risk of hypercalcemia increases, with furosemide and other "loop" diuretics, the excretion of calcium by the kidneys increases. Calcemin® Advance should not be used in conjunction with calcium channel blockers. It is not recommended to take the drug simultaneously with antacids that contain aluminum, due to a decrease in their effectiveness.

Overdose

Vitamin D3 hypervitaminosis, hypercalcemia and hypercalciuria. Symptoms: thirst, polyuria, decreased appetite, constipation, nausea, vomiting, dizziness, muscle weakness, headache, fainting, coma, fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, urolithiasis, in severe cases - cardiac arrhythmias. With prolonged use in doses over 2500 mg of calcium - kidney damage, calcification of soft tissues. If the first signs of an overdose are found, it is necessary to reduce the dose or stop using the drug, consult a doctor. In the case of hypercalciuria exceeding 7.5 mmol / day (300 mg / day), it is necessary to reduce the dose or stop taking the drug. Treatment: rehydration, the use of loop diuretics (eg furosemide), glucocorticosteroids, calcitonin, bisphosphonates, in severe cases, hemodialysis. In case of accidental overdose, induce vomiting, rinse the stomach. Therapy is symptomatic.

Storage conditions

keep away from children

Information provided

Calcemin Advance is a complex drug that helps to correct the level of phosphorus-calcium metabolism in blood plasma. The medicine is prescribed for adults and children for the complex treatment and prevention of diseases of the musculoskeletal system. Instructions for the use of Calcemin Advance will allow you to familiarize yourself in detail with the pharmacological action of the drug.

Calcemin Advance is a combined preparation that contains micro- and macroelements, vitamins; the pharmacological action is due to the properties of the components that make up it:

Calcium increases the density and resection of bone tissue, participates in its formation, reduces resorption, helps to strengthen joints and bone tissue. Calcium citrate normalizes calcium absorption, regardless of the state of the gastrointestinal tract, which allows patients with a reduced gastrointestinal tract secretory function to take the drug; reduces the level of markers of bone tissue, which indicates a slowdown in the processes of its destruction; regulates the calcium content, respectively, prevents the formation of kidney stones; promotes the absorption of iron, thereby significantly reducing the risk of developing IDA, regulates the content of parathyroid hormone in the blood, which improves the regulation of calcium homeostasis.
Colecalciferol (vitamin D 3) regulates and replenishes the exchange of calcium and phosphorus, effectively strengthens the structure of bones, affects the reabsorption of phosphorus in the renal canals and the absorption of calcium in the intestine.
Zinc helps to strengthen bone tissue and has a beneficial effect on the synthesis of sex hormones.
Magnesium contributes to the formation of muscle and bone tissue. Magnesium and zinc are required by the human body for the process of synthesizing the organic bone matrix.
Copper regulates the process of collagen synthesis, having a positive effect on the formation of bone mass.
Manganese forms the bone matrix, participates in the formation of proteoglycans, thereby improving bone strength.
Boron improves the absorption of calcium, reduces the activity of parathyroid hormone, reduces the risk of developing cholecalciferol deficiency, and prevents the development of osteoporosis.

Release form

Dosage form: tablets.

Tablet color: pink.

Shape: biconvex, oval, risk on one side.

Packing type: polyethylene bottle, each packed in a cardboard box.

The drug is available in 3 dosages: 30, 60, 120 pcs. in each bottle.

Composition of the preparation

Active ingredients in one tablet:

calcium (calcium carbonate, calcium tetrahydrate);
colecalciferol (vitamin D 3);
magnesium (magnesium oxide);
zinc (zinc oxide);
copper (copper oxide);
manganese (manganese sulfate);
boron (sodium borate decahydrate).

Excipients:

core: maltodextrin, sodium lauryl sulfate, soy polysaccharide, stearic acid, croscarmellose sodium, microcrystalline cellulose;
shell: mineral oil, hypromellose, titanium dioxide, triacetin, magnesium silicate, aluminum varnish (Red No. 40) - 0.315 mg; aluminum varnish (Yellow No. 6) - 0.078 mg, aluminum varnish (Blue No. 1) - 0.05 mg.

Instructions for use

Calcemin Advance has several indications for use. His doctors prescribe for the complex treatment of diseases of the musculoskeletal system and for prophylactic purposes.

The medicine does not relieve the inflammatory process, pain, does not have an antimicrobial effect, does not help at temperatures, it has a different mechanism of action - it provides the body with the necessary microelements and vitamins.

therapy and prevention of osteoporosis;
treatment of many diseases of the musculoskeletal system;
improving the consolidation of fractures and injuries;
long-term use of immunosuppressants;
bone resorption treatment;
period of menopause;
lack of calcium;
preventive measures in dentistry;
replenishment of reserves of trace elements and minerals during a period of increased demand (development of the musculoskeletal system, fractures, pregnancy, lactation).

Before you start taking the drug, you need to consult a specialist.

Kalcemin Advance for children

Indications for use of the medicine for children:

deficiency of vitamins and minerals;
diseases of the musculoskeletal system;
injuries, fractures, etc.

The dosage of the drug is determined by a specialist after a comprehensive examination.

Pregnancy and lactation

During pregnancy or lactation, Calcemin Advance can only be taken as directed by a doctor. It is forbidden to exceed the dosage of the drug prescribed for this period, since an excess of calcium in the body of a pregnant woman negatively affects the development of the fetus - it leads to hypercalcemia, aortic stenosis syndrome, epilepsy. Also, the fetus may experience developmental delay and lack of growth.

When breastfeeding, it should be borne in mind that the components of the drug enter the child's body, therefore it is recommended to take the drug under the supervision of a specialist.

Drug interactions

Calcemin Advance is able to reduce the effectiveness of certain drugs: antibiotics, antiviral agents, fluorides, phosphates, diuretics, antacids, while the amount of absorbed calcium decreases. With the simultaneous use of several drugs, including Calcemin Advance, you need to notify the doctor about this.

Also, due to the use of orlystan, ion-exchange salts and laxatives, the absorption of vitamin D3 can be significantly reduced. It is recommended to take a break of several hours between their meals. Phenytoin, carbamazepine, barbiturates, vitamin A can interfere with the absorption of vitamin D3.

Contraindications

This complex drug has some contraindications. Before buying it, be sure to read the instructions. The drug Calcemin Advance has absolute and relative contraindications.

Absolute contraindications include:

vitamin D hypervitaminosis;
hypercalciuria;
hypercalcemia;
severe history of renal failure;
sarcoidosis;
tuberculosis;
intolerance to the components of the drug;
age up to 12 years;
urolithiasis disease;
allergy to peanut butter, soy.

Relative contraindications (conditions / diseases in the presence of which the prescription of a medicine requires caution and specialist supervision):

pregnancy and lactation;
renal failure.

Dosage

The dosage of Calcemin Advance depends on the etiology of the disease. The complex remedy is taken with meals. Before taking the drug, you should read the annotation in which the Calcemin Advance regimen is recommended:

osteoporosis (prevention): 1 tab. - once a day, application - 2 months;
osteoporosis (as part of complex treatment): 2 times a day - 1 table, duration - 3 months;
replenishment of calcium deficiency, improvement of the consolidation of traumatic fractures: once a day, 1 table, application - 2 months.

Side effects

Most often, Calcemin Advance has no side effects, but with individual intolerance to the components, sensitivity or prolonged use of the drug, some side effects may develop:

headache;
allergic reactions - redness, rashes, hives, dry skin;
on the part of the digestive tract - increased gas production, abdominal pain, nausea, lack of appetite, a feeling of heaviness in the stomach;
changes in blood and urine tests - hypercalciuria and hypercalcemia.

Price

Calcemin Advance tablets are sold in dosages - 30, 60, 120 pcs. packaged. If the treatment is several months, then the manufacturer offers to save significantly when buying 60 or 120 tablets. packaged. This complex drug can be purchased in the pharmacy chain, in the online store and ordered from the catalog.

Cost of Calcemin Advance in network pharmacies (average prices):

Analogs

Calcemin Advance has no structural analogs for the main active substance. However, on the pharmaceutical market there are many similar medicines based on vitamins and microelements.

Vitrum Osteomag (tablets). Manufacturer: Unipharm Inc. (USA). The drug has differences in composition, but it is used when the same problems arise as Calcemin Advance: osteoporosis, calcium deficiency, vitamin D3, for therapeutic and prophylactic purposes. Contraindicated under the age of 12 years and with increased sensitivity of the body to the components of the drug. Available in tablet form: price from 378 rubles.
Calcium-D3 Nycomed (chewable tablets). Manufacturer: Nycomed Pharma AS (Norway). Contains a voluminous list of contraindications, as well as age restrictions. Calcium-based preparation, produced in the form of chewable tablets: 30 pcs., Price from 221 rubles.

Cheap analogues of Calcemin Advance:

Complivit calcium D3 (chewable tablets)... Manufacturer: Pharmstandard-UfaVITA (Russia). The drug is in the same pharmacological group as Calcemin Advance, however, it contains only two active ingredients. The indications for use contain the same points. Sold in the form of chewable tablets: 30 pieces, price from 138 rubles.

Overdose

Overdose of the drug can lead to hypervitaminosis, hypercalciuria, hypercalcemia.

Overdose symptoms of the drug: decreased appetite, headache, dizziness, thirst, polyuria, nausea, vomiting, constipation, fatigue, muscle weakness, bone pain, fainting, coma, mental disorders, urolithiasis, rarely - cardiac arrhythmias.

Long-term use of calcium can provoke soft tissue calcification, kidney inflammation.

Overdose treatment. If signs of overdose are found, it is necessary to immediately reduce the dose or stop using the drug. If the overdose is caused by accidental circumstances, induce vomiting and flush the stomach. In special cases, symptomatic therapy is performed.

Calcemin Advance is a regulator of calcium-phosphorus metabolism. The role of calcium in the public mind is often limited to the formation of bone tissue. But these functions in the body are far from being exhausted: calcium regulates the permeability of the walls of blood vessels, the conduction of impulses through neurons, participates in contractions of skeletal muscles, and is one of the components of the blood coagulation system. Normal absorption of calcium is possible only in the presence of active alkaline phosphatase, which requires vitamin D to activate. the latter tends to accumulate in the body, which, in turn, is fraught with hypervitaminosis. Vitamin D hypervitaminosis can cause the development of cardiovascular, nervous and hepatic pathologies. In this regard, clinicians were forced to limit the duration of treatment with preparations containing vitamin D in a dose of more than 400 IU, which reduced the risk of developing hypervitaminosis, but at the same time the effectiveness of pharmacotherapy. The latter had a negative impact on persons with increased calcium requirements, for example, on pregnant women. The solution was found by the specialists of the pharmaceutical company SAGMEL. In addition to calcium and vitamin D, their Calcemin Advance also contains zinc, copper, manganese and boron, which also contribute to the best absorption of calcium, which made it possible to reduce the dose of vitamin D without losing the effectiveness of treatment.

Zinc activates more than 200 enzymes, including alkaline phosphatase. Copper takes part in the formation of structural proteins collagen and elastin, preventing a decrease in bone mineral density. Manganese ensures the normal formation of mucopolysaccharides, which are necessary for the formation of bones and cartilage. Boron controls the activity of parathyroid hormone, which is involved in calcium-phosphorus metabolism, the metabolism of magnesium and vitamin D. lack of calcium and magnesium. The drug is contraindicated in case of individual intolerance to one or more components, nephrolithiasis, an increase in the concentration of calcium in the blood plasma, urinary excretion per day more than 250 (in women) and 300 (in men) mg of calcium. In pediatrics, Calcemin Advance is used from the age of 12. The frequency of admission in adults and children is twice a day. Single dose - 1 tablet. It is not recommended to exceed the dose set by the manufacturer, because Excess calcium can cause impaired absorption of iron, zinc and other trace elements. During pregnancy and breastfeeding, taking the drug should be agreed with your doctor.

Pharmacology

Combined drug. Regulates calcium-phosphorus metabolism. Replenishes the deficiency of calcium, vitamin D 3, magnesium, microelements. Promotes strengthening of bones and joints, prevents diseases of the musculoskeletal system.

Pharmacokinetics

Data on the pharmacokinetics of Calcemin Advance are not provided.

Release form

Tablets, film-coated pink, elongated, capsule-shaped, with a notch squeezed out on one side.

Excipients: maltodextrin - 62.66 mg, microcrystalline cellulose - 50 mg, sodium croscarmellose - 38 mg, acacia - 37.96 mg, stearic acid - 16.33 mg, soy polysaccharide - 15 mg, titanium dioxide - 8.55 mg, sodium lauryl sulfate - 5 mg.

Shell composition: hypromellose (hydroxypropyl methylcellulose) - 17.47 mg, magnesium silicate - 5 mg, triacetin - 3.85 mg, mineral oil - 1.92 mg, FD&C red No. 40 varnish - 210 μg, FD&C yellow No. 6 varnish - 53 μg, FD&C blue No. 1 varnish - 27 mcg.

30 pcs. - polyethylene bottles (1) - cardboard packs.
60 pcs. - polyethylene bottles (1) - cardboard packs.
120 pcs. - polyethylene bottles (1) - cardboard packs.

Dosage

Adults and children (over 12 years old) - 1 tab. 2 times / day The drug is administered orally during meals.

Overdose

Symptoms: constipation, nausea and vomiting, hypercalcemia and hypercalciuria.

Treatment: drug withdrawal, symptomatic therapy.

Interaction

Data on drug interactions of the drug Calcemin Advance are not provided.

Side effects

From the digestive system: nausea, vomiting, flatulence.

From the side of metabolism: hypercalcemia and hypercalciuria.

Others: allergic reactions.

Indications

Prevention and complex treatment of osteoporosis of various origins:

in women during menopause (natural and surgical);
in persons taking long-term corticosteroids and immunosuppressants.

Therapy of diseases of the musculoskeletal system:

to improve the consolidation of traumatic fractures.

To replenish the deficiency of calcium and trace elements in adolescents.

Medicines help maintain optimal health. Vitamins and minerals are sometimes needed by the body to a greater extent than serious medications, since they allow starting biological mechanisms that help accelerate the healing process.

One of these essential means for the body is the Calcemin family of drugs (Silver and Advance), which are successfully used in various fields of medicine.

The main active component of the drug is calcium, which is the basis in building strong bones, and is also actively involved in regulating the permeability of the walls of blood vessels, therefore it is used during the treatment of diseases associated with veins and blood vessels.

Also, the substance is involved in the regulation of the conductivity of the synapse, in the contractile activity of the muscles. Calcium is indispensable in blood clotting processes, and therefore prevents or slows down the formation of clots - blood clots. The drug Calcemin and its analogs belongs to the pharmacological group of drugs for phosphorus - calcium metabolism.

The drug is available in the form of three types of tablets (Calcemin, as well as the Advance and Silver series). They can be:

covered with a film sheath;
have a simple shell.

Packaging can be a simple cardboard box or bottle. The number of tablets is from 30 to 120 pieces. It is important to remember that vitamin D can be purchased separately - it is sold in the form of drops. The composition of the Kalcemin preparation:

active- calcium, zinc, copper, manganese, boron, D3;
subsidiary- polysaccharide (soy), sodium compounds, stearic acid.

The shell also contains magnesium, as well as other substances and compounds - hypromellose, triacitin, mineral oil, titanium dioxide.

Pharmacological profile

The main effect of the drug is the regulation of metabolic processes in the body. Also, the substances that make up Calcemin make up for their lack in the body, calcium is the main component that strengthens bones, making them less susceptible to mechanical stress and negative processes in the body, and vitamin D3 accelerates its absorption from the body.

Strengthening the joints has a positive effect on the dynamics of the treatment of many diseases of the musculoskeletal system.

The main active components of the drug are absorbed from the gastrointestinal tract, including vitamin D, the place of absorption of which is the small intestine. After ingestion, it is excreted from the body:

with feces;
with urine;
with sweat.

The components of the drug penetrate into all organs and tissues, including the fatty layer, through the blood and lymph. After this, the process of excretion of substances with bile into the intestine takes place, where they are partially absorbed, turning into inactive metabolites.

Magnesium is also absorbed in the digestive tract. It is excreted in the bile - up to 90%, the rest of it - with solid masses (feces). An insignificant part is processed and excreted by the kidneys in the form of compounds that are readily soluble in water.

Zinc is absorbed in the intestines. The substance is excreted in greater quantities with feces - about 90%, the rest - with urine (about 10%). Has a positive effect on enzymes produced in the body.

Copper is not completely absorbed, but to the extent that the body needs. Usually it is about 30% of the amount contained in the preparation. Absorption is carried out by the intestines. The remainder (about 70%) is removed with solid masses. In turn, the absorbed copper is excreted in the bile (80%), the walls of the gastrointestinal tract (16%). Only about 4% of the substance remains in the urine. Percentage shares are displayed with sweat.

Boron, also part of Calcemin, normalizes hormones. It is rapidly absorbed from the gastrointestinal tract. It is excreted (up to 90%) in the urine. The rest - with feces and sweat.

Mechanism of action

Calcemin is effective for various calcium deficiencies in bones and joints. Penetrating into the body, the components of the drug begin to work actively, filling the "empty spaces".

Calcium and other substances that form the agent make all biological processes work - it normalizes hormonal levels, to stabilize enzymes and strengthen bone and cartilage tissues. All this together allows us to guarantee a good result regarding the work of the ODA and other systems and organs in need of treatment. Significant improvement becomes noticeable as early as 7-10 days after the start of admission.

Relief of the condition (depending on the disease) is noted 4-5 days after the start of taking the drug.

Indications for use

After passing a preliminary examination, the doctor prescribes Calcemin in the following cases:

identified;
lack of vitamins and minerals in the body (based on test results);
prevention and treatment of diseases of the oral cavity (teeth strengthening);
treatment of the consequences of fractures and cracks in the limbs;
the period of menopause of a different nature (surgical or natural);
prevention of vitamin deficiencies.

Calcemin is also prescribed during pregnancy, but only according to indications. Children are prescribed during the period of active growth and development of the skeleton - from 5-6 years.

Restrictions for appointment

Taking the drug is prohibited if the patient has:

there are severe allergic reactions;
there is hypersensitivity to the substances included in the drug or to their group;
urolithiasis disease;
an excess of calcium in the body;
metabolic disorders have been noted;
tuberculosis (active form);
tumors (myeloma, sarcoidosis,);
children's age up to 5 years (up to 12 if Calcemin Advance is prescribed);
hypervitaminosis D3.

With caution and under the supervision of a physician, it is possible to receive if a history of:

benign granulomatosis;
taking cardiac glycosides;
a course of thiazide diuretins;
pregnancy at all stages;
lactation period.

In these cases, the doctor may order additional tests to monitor changes in the body.

Instructions for use

The drug in any form is taken orally during meals. If the doctor has not prescribed other dosages, then the recommendations for admission will be as follows:

In any form, it is treated with the use of 1 tablet of the drug per day. The course of treatment or prophylaxis in this case is 1 to 3 months (30 to 90 days) and depends on the severity and degree of neglect of the disease. If the medicine is prescribed for a deficiency of calcium and other trace elements in children and adults, then the intake lasts 2-3 months.

Overdose and side effects

In case of an overdose of Calcemin, it is primarily possible to develop hypervitaminosis D, as well as hypercalcemia and hypercalciuria. Symptoms by which you can determine that taking a given amount of medication is harmful to the body:

If you do not take measures to reduce or adjust the dose taken, then a serious violation can develop - calcification of blood vessels and tissues. In this case, long-term treatment in a hospital setting will be required.

Overdose treatment - cancellation or reduction of the amount of the drug to a minimum. If the excess happened by accident, then you need to induce an attack of vomiting. In special cases, special therapy is prescribed.

Side effects of the drug are expressed in disorders of the gastrointestinal tract and the development of hypercalcemia. Allergic manifestations such as itching, hives and rashes may also occur.

Interaction with other medications

When used simultaneously with vitamin A, side effects from taking vitamin D3 are reduced. Substances such as phenytoin reduce the effectiveness of vitamin D3. In turn, taking laxatives reduces the absorption of this vitamin. Calcium will be absorbed worse if hormonal or contraceptives are taken simultaneously with the drug.

Tetracyclines and Calcemin should be taken 3-4 hours apart. If heart problems are noted and the use of special agents is indicated, then Calcemin can cause toxicity of glycosides, therefore, an ECG is necessary to monitor the results of treatment and the safety of the patient.

The complex should not be used in conjunction with calcium channel blockers. It is also not recommended to take the drug simultaneously with antacids containing aluminum, since the drug reduces their effectiveness.

Combined preparation containing calcium, vitamin D3, osteotropic minerals that regulate calcium metabolism.
The pharmacological action of the drug is determined by the properties of its constituent ingredients.
Calcium is involved in the formation of bone tissue, reduces resorption (resorption) and increases bone density, prevents diseases of the musculoskeletal system, helps to strengthen the skeletal system and joints.
Calcium citrate ensures the absorption of calcium, regardless of the functional state of the gastrointestinal tract, which is applicable for the treatment of patients with reduced secretory function of the gastrointestinal tract, as well as during treatment with drugs to reduce secretion; reduces the level of markers of bone resorption, which indicates a slowdown in the processes of destruction of bone tissue; regulates the level of parathyroid hormone, which leads to an improvement in the regulation of calcium homeostasis; does not increase the content of oxalates and calcium in the urine, therefore does not cause the risk of kidney stones; does not block the absorption of iron, which reduces the risk of developing iron deficiency anemia.
Colecalciferol (vitamin D3) regulates the exchange of calcium and phosphorus in the body, participates in the formation of the bone skeleton, helps to preserve the structure of bones, enhances the absorption of calcium in the intestine and the reabsorption of phosphorus in the renal tubules.
Zinc promotes the synthesis of sex hormones, which prevents the destruction of bone tissue.
Manganese is involved in the formation of proteoglycans, which improves the quality of bone tissue and forms the protein matrix of bone tissue.
Copper is involved in the synthesis of collagen and elastin, which is part of bone and connective tissue, which affects the formation of bone mass.
Boron reduces the excessive activity of parathyroid hormone, improves calcium absorption, reduces the risk of developing cholecalciferol deficiency, and helps prevent osteoporosis.

Indications for use:
The drug is recommended for use for the prevention and treatment of osteoporosis, replenishment of calcium and micronutrient deficiencies in adolescents, replenishment of calcium and micronutrient deficiencies in women during pregnancy and during breastfeeding.

Mode of application:
The tablets are taken before meals or with meals.
For children over 12 years old and adults - 1 tablet 2 times a day. Children from 5 to 12 years old - 1 tablet 1 time per day. The duration of therapy is determined individually, there is no time limit.
With a deficiency of calcium and trace elements, 1 tablet is prescribed per day.

Side effects:
Rarely, when using the drug, side effects such as nausea, vomiting, flatulence, hypercalcemia, hypercalciuria, and allergic reactions are possible.

Contraindications:
Contraindications to the use of the drug are: hypersensitivity to the components of the drug, hypercalciuria, hypercalcemia, kidney stones.
With caution - benign granulomatosis, taking cardiac glycosides and thiazide diuretics, pregnancy, lactation.

Pregnancy:
Pregnant women from the 20th week and lactating mothers are prescribed 1 tablet 2 times a day.
The drug is prescribed no earlier than 20 weeks of pregnancy.

With the simultaneous use of the drug with vitamin A, the toxicity of vitamin D3 decreases. Phenytoin, barbiturates, glucocorticoids reduce the effectiveness of vitamin D3. Laxatives reduce the absorption of vitamin D3.
Glucocorticoids, hormonal contraceptives for systemic use, levothyroxine impair the absorption of calcium ions. With the simultaneous use of tetracyclines, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is disturbed) - at least 2 hours. With the combined use of the drug Calcemin with cardiac glycosides, their toxicity increases (monitoring of the ECG and the clinical state is necessary), with thiazide diuretics - the risk of hypercalcemia increases, with furosemide and other "loop" diuretics - the excretion of calcium by the kidneys increases. Calcemin should not be used in conjunction with calcium channel blockers. It is not recommended to take the drug simultaneously with antacids that contain aluminum, due to a decrease in their effectiveness.

Overdose:
Vitamin D hypervitaminosis, hypercalcemia and hypercalciuria.
Overdose symptoms: decreased appetite, thirst, polyuria, dizziness, fainting, constipation, nausea and vomiting. With prolonged use of excessive doses, vascular and tissue calcification. In this case, it is necessary to reduce the dose or stop using the drug. In case of accidental overdose, induce vomiting, rinse the stomach. Therapy is symptomatic.

Storage conditions:
store in a dry place out of the reach of children at a temperature of 15 ° to 30 ° C.
Shelf life is 3 years.

Release form:
Calcemin tablets coated white, capsule-like, notched on one side; 30, 60 or 120 tablets per pack.

Compound:
The drug contains: calcium (calcium citrate and calcium carbonate) 250 mg, colecalciferol (vitamin D3) 50 IU, copper 0.5 mg, zinc 2 mg, boron 50 μg, manganese 0.5 mg.
Excipients: maltodextrin, microcrystalline cellulose, croscarmellose sodium, acacia, stearic acid, soy polysaccharide, magnesium stearate.

Additionally:
When using the drug, the recommended doses should not be exceeded. increased calcium intake can inhibit intestinal absorption of iron, zinc and other essential minerals.
.

During pregnancy, a woman needs additional intake of calcium and minerals to form the fetal skeletal system. Therefore, doctors prescribe an appropriate diet and calcium-containing medications to the expectant mother. Calcemin during pregnancy ensures the prevention of osteoporosis in the mother and the normal development of the unborn child.

Like any drug, it has features of its use. Consider the contraindications and indications for taking Kalcemin, its analogues and composition.

Calcemin is a complex preparation containing a balanced amount of minerals and vitamins. Its name indicates that the main active ingredient is calcium. The presence of vitamin D3 in the composition of Calcemin is extremely important, which ensures the absorption of calcium by the body.

Each of the components of the drug performs important functions in our body. Calcium is involved in the following processes:

the formation of bone structure and cartilage;
ensuring the contractile function of muscles, bone strength;
strengthening the walls of blood vessels;
increasing the elasticity and strength of the tendon-ligamentous apparatus of the joints, spine;
regulation of blood clotting;
maintaining homeostasis of the acid-base environment.

In addition to calcium, the preparation contains several more chemical elements. Each of them deserves a separate consideration.

Zinc is a component of bone tissue, cartilage and tendons, performs a number of functions:

ensures the growth of bones and ligaments;
promotes the processes of regeneration of bones and joints in case of damage;
participates in protein metabolism;
is a structural component of a number of enzymes and hormones.

Manganese is important for its participation in the construction of osteo-ligamentous structures, muscle contractions. It is also essential for biochemical and enzymatic reactions.

Copper is part of collagen and elastin. These proteins form the basis of ligaments, tendons, and cartilage. This chemical element is needed for normal metabolism, hematopoietic activity of the bone marrow, and the functioning of the most important organs.

Boron improves calcium-phosphorus metabolism indirectly by acting on the parathyroid glands. It stops the leaching of calcium from bone structures and the development of osteoporosis during pregnancy. In addition, boron prevents the accumulation of calcium in internal organs, vascular walls, increases the activity of vitamin D.

Cholecalciferol (vitamin D3) also provides important processes:

regulation of calcium and phosphorus metabolism;
absorption of minerals from the intestines;
effective incorporation of calcium into bone structures;
acceleration of the regeneration processes of damaged or overworked muscles, tendons, bones, their strengthening.

Indications and contraindications

Calcemin is used for prophylactic and therapeutic purposes. Indications for prescribing to pregnant women and young mothers are prevention and treatment of osteoporosis, elimination of calcium deficiency symptoms.

Contraindications to taking Calcemin:

pregnancy is less than 20 weeks;
chronic renal dysfunction;
the presence of stones in the urinary system;
individual intolerance to the components;
increased concentration of ionized calcium in the biochemical blood test, in the urine;
excess content of cholecalciferol in the blood.

Can the drug be used during pregnancy?

Lack of calcium leads to many negative consequences, especially for the body of the expectant mother. Fragility of bones, caries occurs, hair falls out. Women with calcium deficiency more often go to doctors because of early toxicosis, they are worried about pain in the joints, at night. Hypertensive crises, pain in the heart are often observed.

Therefore, during pregnancy, taking calcium-containing preparations fortified with minerals and vitamins is very important. Otherwise, a woman may develop osteoporosis, and a future baby may have a violation of the formation of the skeleton, a number of organs and systems.

But an excessive intake of any, even a useful substance, during the period of gestation can be harmful. Therefore, when choosing calcium-D3-containing preparations, one should be guided by physiological norms of consumption: the daily dose of calcium should not exceed 1.5 g, cholecalciferol - 600 mg. Dosage, frequency of administration, duration of the course must be agreed with the attending doctor.

Taking Calcemin is usually recommended with. It is at this time that the active formation of the child's skeletal system begins. In case of bone fractures and signs of calcium deficiency, the drug can be prescribed at the initial stages of gestation.

Calcemin or Calcemin Advance?

These drugs are produced by one company, the components of the vitamin-mineral complex are the same. The differences concern only the content of the active ingredients. Calcemin Advance contains them in higher doses. Therefore, Calcemin is used prophylactically to normalize calcium metabolism in pregnant women.

Calcemin Advance is a medicinal product prescribed in the following cases:

damage to the musculoskeletal system, fractures;
age-related osteoporosis;
the need for long-term use of corticosteroid hormones, anticancer drugs, immunosuppressants and other drugs that cause increased fragility of bones.

Calcemin Advance is prescribed for pregnant women only on strict indications.

Ingredient content	Kalcemin	Kalcemin Advance
Calcium Citrate	840 mg	217 mg
Calcium carbonate	200 mg	1312 mg
Vitamin D3	50 IU	200 IU
Manganese	5 mg	1.8 mg
Zinc	2 mg	7.5 mg
Copper	0.5 mg	1 mg
Boron	50 mcg	250 mcg

How to take Calcemin?

For prophylactic purposes, the drug is used for a month, 1 tablet before meals or during meals 2 times a day. Usually it is prescribed from the 20th week.

After 35 weeks of pregnancy, Calcemin cannot be taken, as this leads to accelerated ossification of the fetal skull, complicating the process of childbirth. In case of a gross violation of mineral metabolism, gynecologists prescribe the drug already in the early stages of pregnancy.

It is important to drink Calcemin with a sufficient amount of liquid or dairy products, this improves the absorption of calcium, increases the effectiveness of the drug.

The instruction also indicates a number of undesirable consequences of taking the drug. Most often, the following side reactions are of concern: allergies (itching, urticaria), disorders of the digestive system - abdominal pain, nausea, unstable stools. If you experience any discomfort, you must stop taking and consult a doctor to replace the drug.

Analogs

For the treatment and prevention of calcium deficiency during pregnancy, many drugs have been synthesized. The following remedies are most popular:

Complivit calcium D3. It normalizes mineral metabolism, it is prescribed 1 tablet per day for a month.
Calcium + Vitamin C. Recommended for bearing the fetus and during lactation, with overload, asthenic conditions. The duration of treatment is determined by the doctor.
Citra-calcemin. It is widely used during pregnancy, the main active ingredient of the drug is calcium citrate.
Calcium-D3 Nycomed. Contains calcium and vitamin D3. The trace elements that make up Calcemin are absent in this preparation, which is its disadvantage.
Vitrum Osteomag. Complex preparation, which contains vitamin D, calcium, magnesium, copper, manganese, zinc, boron.

Calcemin during pregnancy is effective for eliminating calcium deficiency in the body and improving mineral metabolism. It is an optimally balanced vitamin and mineral complex that rarely causes undesirable consequences.

Taking Kalcemin, expectant mothers note the normalization of their well-being: the symptoms of toxicosis pass, and their mood improves. But self-medication is unacceptable. Only a doctor can determine the required duration of treatment and select a drug taking into account individual characteristics.

Useful video: why is calcium so important for pregnant women?

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INSTRUCTIONS CALCEMINE ADVANCE

pharmachologic effect Kalcemin Advance:

Mineral and vitamin complex. Calcium, which is part of the drug, is a building component for bone tissue, regulates the permeability of the vascular wall, participates in the regulation of conductivity in synapses and neuromuscular joints, participates in the contractile activity of skeletal and smooth muscles, is a necessary component for the process blood coagulation. Calcium is presented in the preparation of carbonate and citrate salts. Calcium carbonate contains the maximum amount of elemental calcium. Calcium citrate reduces the dependence of the process of bioavailability of calcium on the state of the gastrointestinal mucosa, prevents calculus formation in the urinary system even in the case of prolonged use, reduces excess production of parathyroid hormone ...

Vitamin D (cholecalciferol) promotes adequate absorption of calcium, participates in the processes of regeneration and building of bone tissue.

Zinc is an integral component of various enzymes in the body (more than 200 species) that synthesize proteins and nucleic acids. It also provides gene expression, regeneration and cell growth. It has a positive effect on the activity of the enzyme alkaline phosphatase.

Manganese promotes the synthesis of substances that are components of bone and cartilage tissue (glycosaminoglycans). It potentiates the calcium-saving ability of vitamin D.

Copper is involved in the formation of elastin, collagen and helps to stop the phenomenon of demineralization of bone structures.

Boron normalizes the activity of the parathyroid hormone - parathyroid hormone. The latter is involved in the exchange of calcium, cholecalciferol, phosphorus, magnesium. The effect on the mineral metabolism of parathyroid hormone does not depend on the intake of vitamin D3.

Calcium is absorbed from the gastrointestinal tract, eliminated from the body with urine, sweat and feces. Calcium absorption is possible due to the activity of calbindin, an enzyme of the intestinal mucosa. Calbindin biosynthesis directly depends on calcitriol, a metabolite of vitamin D.

Vitamin D is rapidly absorbed from the intestines. Penetrates into bones, liver, adrenal glands, adipose tissue, heart muscle. When vitamin D is excreted in bile, its reabsorption is observed. Partially transformed into inactive metabolites.

Zinc is eliminated by the kidneys (10%) and intestines (90%).

Copper is partially absorbed from the intestines, the rest is eliminated unchanged or in the form of insoluble complexes. 80% of the introduced copper is excreted in the bile, 16% - in the intestines, 4% - by the kidneys, a very small amount - by the sweat glands.

Boron after absorption from the intestine is excreted by the kidneys (90%).

Indications for useKalcemin Advance :

Prevention of osteoporosis and other diseases of the musculoskeletal system,

Prevention of dental diseases, periodontal disease,

Replenishment of the deficiency of vitamins and minerals in the event of an insufficient amount in the diet,

Children - during the period of intensive growth,

· Pregnant and lactating women.

Mode of applicationKalcemin Advance :

For children over 12 years old and adults - 1 tablet 2 r / s. Children from 5 to 12 years old - 1 tablet 1 r / s. Tablets are taken before meals or with meals. The duration of therapy is determined individually, there is no time limit. Pregnant and lactating mothers are prescribed 1 tablet 2 r / s. The drug is prescribed no earlier than 20 weeks of pregnancy.

Side effects:

More often observed in case of drug overdose (hypersensitivity reactions to the components of calcemin, nausea, flatulence, vomiting, hypercalciuria, hypercalcemia).

Contraindications:

Hypersensitivity reactions (allergic) to the components of the drug,

Hypercalciuria,

Hypercalcemia,

Kidney stone disease.

Pregnancy:

Not contraindicated during pregnancy and lactation.

Interaction with other medicinal products:

Calcemin should not be used together with calcium antagonist agents.

OverdoseKalcemin Advance :

There are no reports of an overdose of calcemin. If the dose was exceeded, symptomatic treatment is prescribed (gastric lavage, prescription of plenty of drink, eating foods poor in calcium).

Release form:

Tablets containing elemental calcium 250 mg, white, capsule-like, notched on one side. The tablets are packed in a polyethylene bottle. In a bottle of 30; 60; 120 tablets.

Storage conditions:

Shelf life - 3 years at a temperature of 25-30 ° C. Keep away from light. Keep out of the reach of children.

CompoundKalcemin Advance :

Active ingredients: calcium citrate 842 mg, calcium carbonate 202 mg, cholecalciferol 50 IU, copper 0.5 mg, zinc 2 mg, boron 50 μg, manganese - 5 mg.

Inactive substances: microcrystalline cellulose, magnesium stearate, acacia, sodium lauryl sulfate, croscarmellose sodium, starch, cottonseed oil, calcium phosphate, gluten, sodium citrate, stearic acid, hydroxypropyl cellulose, maltodextrin, sugar, hydroxypropyl methylcellulose, gelatin dioxide, titanium dioxide

Additionally:

At the age of 5 years, it is possible to use the drug only under strict indications. The drug for children of this age should be taken only under the supervision of a doctor.

PRICE OF CALCEMINE ADVANCE:
Kalcemin Advance table p / o vial, No. 120 - 102.20 UAH
Calcemin Advance tabl p / o vial, No. 30 - UAH 36.41

Calcemin Advance is a combined preparation that regulates the exchange of phosphorus and calcium. This remedy eliminates the deficiency of trace elements, calcium and magnesium, provides the body with vitamin D3. The action of the drug "Calcemin Advance" is described by doctors as an action aimed at improving the condition of bones and joints, which can significantly reduce the likelihood of developing diseases affecting the musculoskeletal system.

Composition and form of release "Calcemin Advance"

The tool is available in the form of tablets that have a shell. There can be 30, 60 or 120 of them in a package. The tablets contain sodium carbonate and borate, vitamin D3. Also, the preparation contains copper and zinc in the form and manganese in the form of sulfate.

In the production of a product from excipients, microcrystalline cellulose, croscarmellose sodium is used. Components of the same action include maltodextrin. Additionally, soy polysaccharide, acacia, stearic acid are used.

The shell is formed from magnesium silicate, hypromellose, mineral oil, triacetin, dyes.

pharmachologic effect

The drug "Calcemin Advance" instructions for use, reviews are presented as a means that inhibits the resorption of bone tissue, enhances its density.

The tool successfully combats the lack of vitamin D3 and calcium. It is used to mineralize teeth. The presence of the required amount of calcium ensures the normal regulation of neuromuscular conduction. This element is involved in the process of blood clotting, vitamin D3 contributes to its better absorption after the drug enters the intestines. "Calcemin Advance", influencing the production of parathyroid hormone, maintains its amount in the norm. In this way, the increase in bone resorption is stopped.

Metabolism occurs in the liver, the metabolites formed as a result of this process are excreted by the kidneys.

Indications for the use of "Calcemin Advance"

For osteoporosis, take "Kalcemin Advance". Instructions, reviews show that the drug is prescribed both for complex treatment and for the prevention of this disease in the following cases:

menopause (surgical, natural);
long-term use of immunosuppressants, corticosteroids.

The use of vitamins is carried out in order to implement therapy for lesions of the musculoskeletal system, when the main task is to improve the consolidation of fractures resulting from traumatic effects.

Doctors prescribe this remedy for adolescents, if necessary, to eliminate the deficiency of calcium and trace elements. For the same purpose, tablets are used with increased physical activity.

Carrying a baby, lactation

The attending physician decides whether the woman needs to use Calcemin Advance tablets. The feedback left after treatment with the drug often informs about the need to take into account that vitamin D3 and metabolites that are formed as a result of metabolism may be present in breast milk. It is important to pay attention to how much this vitamin enters the body from other sources.

Kidney problems

The tablets can worsen the condition of patients with moderate renal impairment. In such cases, medical supervision is needed.

Contraindications for taking "Kalcemin Advance"

In some cases, patients cannot be prescribed Calcemin Advance. Instructions for use, reviews for such cases include:

hypersensitivity to components;
age less than 12 years;
the presence of kidney stones;
excretion of large amounts of calcium in the urine;
a pathological condition in which there is an increased content of calcium in the blood plasma.

The use of vitamins

The drug is taken orally while eating. Patients are prescribed a double dose of the drug in a dosage corresponding to one tablet. The duration of the course of therapy is generally 1-1.5 months. It is established by the doctor separately for each case. The maximum dose at one time should not exceed two tablets, the maximum daily dosage should be no more than three tablets. If necessary, the doctor will extend the treatment.

Side effects

After taking Calcemin Advance, a review of the drug may contain some information indicating the possibility of adverse reactions. Possible side effects include allergic reactions, flatulence, vomiting, and preceding nausea. Hypercalciuria or hypercalcemia may also be found. Side effects are possible, but very rare.

Overdose, in addition to the above manifestations, is accompanied by constipation. Irreversible changes in the heart, blood vessels, kidneys are possible. In case of an overdose, the drug is canceled, the stomach is washed, and symptomatic treatment is carried out.

special instructions

When vitamins "Calcemin Advance" are used for therapy, reviews recommend taking the remedy strictly in the prescribed dose, since the intake of a large amount of calcium into the body can cause disturbances in the absorption processes of zinc, iron, and other important substances in the digestive tract.

Since there is some threat to the health of patients with renal failure (expressed moderately), the doctor should regularly monitor the level of calcium in blood plasma and urine.

To avoid an overdose due to an excess of vitamin D3, when planning treatment, all sources from which this substance enters the body should be taken into account.

During pregnancy, the dose corresponding to 600 IU (vitamin) and 1500 mg (calcium) should not be exceeded.

Drug interactions

Regarding the drug interaction of Calcemin Advance, the review is not always positive. This indicates that an independent combination of drugs is sometimes incorrect, which means that you need to consult a doctor to find out the possibility of joint use of "Calcemina Advance" with other drugs.

When vitamins are taken together with barbiturates or "Phenytoin", the activity of the complex may decrease. If sodium fluoride or bisphosphonates are used together, Calcemin Advance may impair their absorption. An interval of 2 hours (minimum) must be observed.

When taken simultaneously with cardiac glycosides, they can enhance their toxic and therapeutic effects. It is important to monitor the clinical condition of patients and have an EKG done regularly.

In cases where calcium-based drugs and tetracyclines are used simultaneously, increased absorption of tetracyclines from the gastrointestinal tract is possible. If it is necessary to use both tetracyclines and Calcemin Advance, the doctors' opinion allows such a possibility. However, the funds must be used so that the interval between their doses is at least three hours.

GCS, laxatives with oils have a bad effect on the absorption of the drug, they slow down this process. Thiazide diuretics used during complex therapy increase the risk of hypercalcemia and increase calcium reabsorption. Loop diuretics increase the release of calcium into the urine.

Reviews, the price of the means "Kalcemin Advance"

The cost is determined by the number of tablets in the "Calcemin Advance" package. Price, reviews are of primary importance when buying a drug. For 30 tablets, you will have to pay approximately from 235 to 400 rubles, 60 tablets of the drug can be purchased for 530-580 rubles. The cost of the drug, the packaging of which includes 120 tablets, is 590-775 rubles.

Judging by the reviews, the drug is often prescribed to strengthen hair and nails. People who have used "Calcemin Advance" for hair loss, reviews are mostly good. For most of them, the drug helps to cope with this problem.

The agent is prescribed to saturate the body with minerals. The advantage of the complex is considered to be an effective combination of macro- and microelements, vitamins. But not everyone likes the presence of additional components that can damage the body. Vitamins are good for bones during menopause, when the body lacks calcium. They are often used during pregnancy to relieve joint and back pain, and as a source of calcium and vitamin D3. It is not for nothing that Kalcemin Advance has so many positive reviews. The drug copes with all its tasks, side effects are rare. To take "Kalcemin Advance", instructions for use, price, reviews are required for study. Taking pills is possible only after a doctor's prescription and in the recommended dose. Then the effect will be maximum, and side effects are unlikely to appear, since they are usually absent in patients.